diethyl (((6-bromothieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonate

Base Information

Chemical Name:diethyl (((6-bromothieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonate
CAS No.:1610772-07-0
Molecular Formula:C₁₇H₁₉BrN₃O₃PS
Molecular Weight:456.3
Hs Code.:

Synonyms:diethyl (((6-bromothieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonate

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Chemical Property of diethyl (((6-bromothieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonate

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Technology Process of diethyl (((6-bromothieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonate

There total 5 articles about diethyl (((6-bromothieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 16814-08-7,42077-95-2,42077-97-4
diethyl 1-aminophenylmethylphosphonate

: 56844-12-3
6-bromo-4-chlorothieno[2,3-d]pyrimidine

: 1610772-07-0
diethyl (((6-bromothieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonate

Guidance literature:: With triethylamine; In 1,4-dioxane; at 100 ℃; for 24h; Sealed tube;

Reference yield:

: 100-52-7
benzaldehyde

: 1610772-07-0
diethyl (((6-bromothieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium(II) perchlorate / 0.25 h

1.2: 24 h / 85 °C

2.1: hydrogen; palladium hydroxide, 20 wt% on carbon / methanol / 72 h / 20 °C / Inert atmosphere

3.1: triethylamine / 1,4-dioxane / 24 h / 100 °C / Sealed tube

With magnesium(II) perchlorate; palladium hydroxide, 20 wt% on carbon; hydrogen; triethylamine; In 1,4-dioxane; methanol;

Reference yield:

: 63000-01-1
diethyl 1-(N-benzylamino)-1-phenylmethylphosphonate

: 1610772-07-0
diethyl (((6-bromothieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium hydroxide, 20 wt% on carbon / methanol / 72 h / 20 °C / Inert atmosphere

2: triethylamine / 1,4-dioxane / 24 h / 100 °C / Sealed tube

With palladium hydroxide, 20 wt% on carbon; hydrogen; triethylamine; In 1,4-dioxane; methanol;