diethyl (((6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonate

Base Information

• Chemical Name: diethyl (((6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonate
• CAS No.: 1615230-76-6
• Molecular Formula: C₂₄H₂₅ClN₃O₃PS
• Molecular Weight: 501.974

Synonyms:diethyl (((6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonate

Chemical Property of diethyl (((6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonate

Chemical Property:

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Technology Process of diethyl (((6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonate

There total 9 articles about diethyl (((6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

diethyl (((6-bromothieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonate (1610772-07-0) + B-(3-chloro-4-methylphenyl)boronic acid (175883-63-3) → diethyl (((6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonate (1615230-76-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 1h;

DOI:10.1021/jm500629e

Reference yield:

diethyl 1-aminophenylmethylphosphonate (16814-08-7,42077-95-2,42077-97-4) + 4-chloro-6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidine → diethyl (((6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonate (1615230-76-6)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 100 ℃; Sealed tube;

DOI:10.1021/jm500629e

Reference yield:

diethyl 1-aminophenylmethylphosphonate (16814-08-7,42077-95-2,42077-97-4) + 6-(3-chloro-4-methylphenyl)-4-fluorothieno[2,3-d]-pyrimidine → diethyl (((6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonate (1615230-76-6)

Guidance literature:

With triethylamine; In dimethyl sulfoxide; at 100 ℃; for 3h; Sealed tube;

DOI:10.1021/acs.jmedchem.6b01888

upstream raw materials:

diethyl 1-aminophenylmethylphosphonate

diethyl (((6-bromothieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonate

B-(3-chloro-4-methylphenyl)boronic acid

thieno[2,3-d]pyrimidin-4(3H)one

Downstream raw materials:

(((6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl)amino)(phenyl)methyl)phosphonic acid

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