5-[4-(2-furan-2-yl-5-methyl-oxazol-4-ylmethoxy)-3-methoxy-phenyl]-2-oxo-pentanoic acid isopropyl ester

Base Information

Chemical Name:5-[4-(2-furan-2-yl-5-methyl-oxazol-4-ylmethoxy)-3-methoxy-phenyl]-2-oxo-pentanoic acid isopropyl ester
CAS No.:207728-19-6
Molecular Formula:C₂₄H₂₇NO₇
Molecular Weight:441.481
Hs Code.:

Synonyms:5-[4-(2-furan-2-yl-5-methyl-oxazol-4-ylmethoxy)-3-methoxy-phenyl]-2-oxo-pentanoic acid isopropyl ester

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Chemical Property of 5-[4-(2-furan-2-yl-5-methyl-oxazol-4-ylmethoxy)-3-methoxy-phenyl]-2-oxo-pentanoic acid isopropyl ester

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Technology Process of 5-[4-(2-furan-2-yl-5-methyl-oxazol-4-ylmethoxy)-3-methoxy-phenyl]-2-oxo-pentanoic acid isopropyl ester

There total 6 articles about 5-[4-(2-furan-2-yl-5-methyl-oxazol-4-ylmethoxy)-3-methoxy-phenyl]-2-oxo-pentanoic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027493-60-2
2-{2-[4-(2-furan-2-yl-5-methyl-oxazol-4-ylmethoxy)-3-methoxy-phenyl]-ethyl}-3-oxo-succinic acid diisopropyl ester

: 207728-19-6
5-[4-(2-furan-2-yl-5-methyl-oxazol-4-ylmethoxy)-3-methoxy-phenyl]-2-oxo-pentanoic acid isopropyl ester

Guidance literature:: With sodium chloride; In dimethyl sulfoxide; at 120 ℃; for 10h;
DOI:10.1021/jm010490l

Reference yield:

: 4-[2-(furan-2-yl)-5-methyl-4-oxazolylmethoxy]-3-methoxybenzaldehyde

: 207728-19-6
5-[4-(2-furan-2-yl-5-methyl-oxazol-4-ylmethoxy)-3-methoxy-phenyl]-2-oxo-pentanoic acid isopropyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 98 percent / NaH / dimethylformamide / 1 h / 0 - 20 °C

2: 93 percent / H₂ / 5percent Pd/C / ethyl acetate / atmospheric pressure

3: 83 percent / NaBH₄ / methanol; tetrahydrofuran / 3 h / Heating

4: 99 percent / Et₃N / ethyl acetate / 0.5 h / 0 - 20 °C

5: 95 percent / dimethylformamide / 2 h / 80 °C

6: 94 percent / 4N aq. KOH / 2-methoxy-ethanol / 2 h / Heating

7: 91 percent / K₂CO₃ / dimethylformamide / 4 h / 65 - 70 °C

8: NaH / toluene; dimethylformamide / 1 h / 100 °C

9: aq. NaCl / dimethylsulfoxide / 10 h / 120 °C

With potassium hydroxide; sodium tetrahydroborate; hydrogen; sodium hydride; potassium carbonate; triethylamine; sodium chloride; 5percent Pd/C; In tetrahydrofuran; methanol; 2-methoxy-ethanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; 1: Horner-Emmons reaction;
DOI:10.1021/jm010490l

Reference yield:

: 178610-70-3
ethyl (E)-4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxycinnamate

: 207728-19-6
5-[4-(2-furan-2-yl-5-methyl-oxazol-4-ylmethoxy)-3-methoxy-phenyl]-2-oxo-pentanoic acid isopropyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 93 percent / H₂ / 5percent Pd/C / ethyl acetate / atmospheric pressure

2: 83 percent / NaBH₄ / methanol; tetrahydrofuran / 3 h / Heating

3: 99 percent / Et₃N / ethyl acetate / 0.5 h / 0 - 20 °C

4: 95 percent / dimethylformamide / 2 h / 80 °C

5: 94 percent / 4N aq. KOH / 2-methoxy-ethanol / 2 h / Heating

6: 91 percent / K₂CO₃ / dimethylformamide / 4 h / 65 - 70 °C

7: NaH / toluene; dimethylformamide / 1 h / 100 °C

8: aq. NaCl / dimethylsulfoxide / 10 h / 120 °C

With potassium hydroxide; sodium tetrahydroborate; hydrogen; sodium hydride; potassium carbonate; triethylamine; sodium chloride; 5percent Pd/C; In tetrahydrofuran; methanol; 2-methoxy-ethanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm010490l