2-{2-[4-(2-furan-2-yl-5-methyl-oxazol-4-ylmethoxy)-3-methoxy-phenyl]-ethyl}-3-oxo-succinic acid diisopropyl ester

Base Information

Chemical Name:2-{2-[4-(2-furan-2-yl-5-methyl-oxazol-4-ylmethoxy)-3-methoxy-phenyl]-ethyl}-3-oxo-succinic acid diisopropyl ester
CAS No.:1027493-60-2
Molecular Formula:C₂₈H₃₃NO₉
Molecular Weight:527.571
Hs Code.:

Synonyms:2-{2-[4-(2-furan-2-yl-5-methyl-oxazol-4-ylmethoxy)-3-methoxy-phenyl]-ethyl}-3-oxo-succinic acid diisopropyl ester

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Chemical Property of 2-{2-[4-(2-furan-2-yl-5-methyl-oxazol-4-ylmethoxy)-3-methoxy-phenyl]-ethyl}-3-oxo-succinic acid diisopropyl ester

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Technology Process of 2-{2-[4-(2-furan-2-yl-5-methyl-oxazol-4-ylmethoxy)-3-methoxy-phenyl]-ethyl}-3-oxo-succinic acid diisopropyl ester

There total 6 articles about 2-{2-[4-(2-furan-2-yl-5-methyl-oxazol-4-ylmethoxy)-3-methoxy-phenyl]-ethyl}-3-oxo-succinic acid diisopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[2-(furan-2-yl)-5-methyl-4-oxazolylmethoxy]-3-methoxybenzaldehyde

: 1027493-60-2
2-{2-[4-(2-furan-2-yl-5-methyl-oxazol-4-ylmethoxy)-3-methoxy-phenyl]-ethyl}-3-oxo-succinic acid diisopropyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / NaH / dimethylformamide / 1 h / 0 - 20 °C

2: 93 percent / H₂ / 5percent Pd/C / ethyl acetate / atmospheric pressure

3: 83 percent / NaBH₄ / methanol; tetrahydrofuran / 3 h / Heating

4: 99 percent / Et₃N / ethyl acetate / 0.5 h / 0 - 20 °C

5: 95 percent / dimethylformamide / 2 h / 80 °C

6: 94 percent / 4N aq. KOH / 2-methoxy-ethanol / 2 h / Heating

7: 91 percent / K₂CO₃ / dimethylformamide / 4 h / 65 - 70 °C

8: NaH / toluene; dimethylformamide / 1 h / 100 °C

With potassium hydroxide; sodium tetrahydroborate; hydrogen; sodium hydride; potassium carbonate; triethylamine; 5percent Pd/C; In tetrahydrofuran; methanol; 2-methoxy-ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene; 1: Horner-Emmons reaction;
DOI:10.1021/jm010490l

Reference yield:

: 178610-70-3
ethyl (E)-4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxycinnamate

: 1027493-60-2
2-{2-[4-(2-furan-2-yl-5-methyl-oxazol-4-ylmethoxy)-3-methoxy-phenyl]-ethyl}-3-oxo-succinic acid diisopropyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / H₂ / 5percent Pd/C / ethyl acetate / atmospheric pressure

2: 83 percent / NaBH₄ / methanol; tetrahydrofuran / 3 h / Heating

3: 99 percent / Et₃N / ethyl acetate / 0.5 h / 0 - 20 °C

4: 95 percent / dimethylformamide / 2 h / 80 °C

5: 94 percent / 4N aq. KOH / 2-methoxy-ethanol / 2 h / Heating

6: 91 percent / K₂CO₃ / dimethylformamide / 4 h / 65 - 70 °C

7: NaH / toluene; dimethylformamide / 1 h / 100 °C

With potassium hydroxide; sodium tetrahydroborate; hydrogen; sodium hydride; potassium carbonate; triethylamine; 5percent Pd/C; In tetrahydrofuran; methanol; 2-methoxy-ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm010490l