N-(5-bromo-2-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)pivalamide

Base Information

Chemical Name:N-(5-bromo-2-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)pivalamide
CAS No.:886049-86-1
Molecular Formula:C₁₇H₂₅BrN₂O₂
Molecular Weight:369.302
Hs Code.:

Synonyms:N-(5-bromo-2-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)pivalamide

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Chemical Property of N-(5-bromo-2-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)pivalamide

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Technology Process of N-(5-bromo-2-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)pivalamide

There total 5 articles about N-(5-bromo-2-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)pivalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 886049-80-5
4-bromo-N₁-((tetrahydro-2Hpyran-4-yl)methyl)benzene-1,2-diamine

: 3282-30-2
pivaloyl chloride

: 886049-86-1
N-(5-bromo-2-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)pivalamide

Guidance literature:: With pyridine; dmap; In dichloromethane; at 20 ℃; Inert atmosphere; Reflux;
DOI:10.1039/c9ob00656g

Reference yield:

: 3460-18-2
1,4-dibromo-2-nitrobenzene

: 886049-86-1
N-(5-bromo-2-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)pivalamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / ethanol / 48 h / 100 °C / Sealed tube; Inert atmosphere

2: ammonium chloride; iron / ethanol; water / 2 h / 40 °C / Inert atmosphere

3: pyridine; dmap / dichloromethane / 20 °C / Inert atmosphere; Reflux

With pyridine; dmap; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; water;
DOI:10.1039/c9ob00656g

Reference yield:

: 886049-79-2
4-bromo-2-nitro-N-((tetrahydro-2H-pyran-4-yl)methyl)aniline

: 886049-86-1
N-(5-bromo-2-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)pivalamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium chloride; iron / ethanol; water / 2 h / 40 °C / Inert atmosphere

2: pyridine; dmap / dichloromethane / 20 °C / Inert atmosphere; Reflux

With pyridine; dmap; iron; ammonium chloride; In ethanol; dichloromethane; water;
DOI:10.1039/c9ob00656g