N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methyl-ethoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide

Base Information

Chemical Name:N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methyl-ethoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide
CAS No.:1262859-65-3
Molecular Formula:C₁₉H₁₆BrF₄N₃O₅S
Molecular Weight:554.317
Hs Code.:

Synonyms:N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methyl-ethoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide

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Chemical Property of N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methyl-ethoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide

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Technology Process of N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methyl-ethoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide

There total 13 articles about N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methyl-ethoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262859-64-2
(R)-2-[(R)-2-(5-bromo-2-fluoro-phenyl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3,3,3-trifluoro-2-methyl-propionamide

: 1262859-65-3
N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methyl-ethoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide

Guidance literature:: With triethylamine; trifluoroacetic anhydride; In dichloromethane; at 0 - 25 ℃; for 4h; Inert atmosphere;

Reference yield:

: 460-00-4
1-Bromo-4-fluorobenzene

: 1262859-65-3
N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methyl-ethoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 11 steps

1: n-butyllithium / hexane; tetrahydrofuran; acetone

2: phosphoric acid / dichloromethane; hexane

3: potassium carbonate; K₃Fe(CN)6; Na₂S₂O₅ / K₂OsO₂(OH)4 / t-BuOH-H₂O

4: hydrogenchloride; sodium hydroxide / dichloromethane

5: ammonium chloride; sodium azide / ethanol

6: NaOH; LiAlH₄ / water; tetrahydrofuran

7: sodium hydroxide / tetrahydrofuran

8: triphenylphosphine / dichloromethane

9: hydrogenchloride; NaH / N,N-dimethyl-formamide; mineral oil

10: ammonia; methanol

11: sodium hydrogencarbonate / dichloromethane

With hydrogenchloride; sodium hydroxide; NaOH; n-butyllithium; sodium azide; LiAlH₄; K₃Fe(CN)6; Na₂S₂O₅; NaH; phosphoric acid; ammonium chloride; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; K₂OsO₂(OH)4; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; t-BuOH-H₂O; ammonia; water; N,N-dimethyl-formamide; acetone; mineral oil;

Reference yield:

: 1206774-43-7
1-(5-bromo-2-fluorophenyl)-1-methylethanol

: 1262859-65-3
N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methyl-ethoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 10 steps

1: phosphoric acid / dichloromethane; hexane

2: potassium carbonate; K₃Fe(CN)6; Na₂S₂O₅ / K₂OsO₂(OH)4 / t-BuOH-H₂O

3: hydrogenchloride; sodium hydroxide / dichloromethane

4: ammonium chloride; sodium azide / ethanol

5: NaOH; LiAlH₄ / water; tetrahydrofuran

6: sodium hydroxide / tetrahydrofuran

7: triphenylphosphine / dichloromethane

8: hydrogenchloride; NaH / N,N-dimethyl-formamide; mineral oil

9: ammonia; methanol

10: sodium hydrogencarbonate / dichloromethane

With hydrogenchloride; sodium hydroxide; NaOH; sodium azide; LiAlH₄; K₃Fe(CN)6; Na₂S₂O₅; NaH; phosphoric acid; ammonium chloride; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; K₂OsO₂(OH)4; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; t-BuOH-H₂O; ammonia; water; N,N-dimethyl-formamide; mineral oil;