6-(3-amino-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)-N-hydroxyhex-5-ynamide hydrochloride

Base Information

Chemical Name:6-(3-amino-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)-N-hydroxyhex-5-ynamide hydrochloride
CAS No.:1449305-72-9
Molecular Formula:C₂₂H₂₂N₄O₃*ClH
Molecular Weight:426.903
Hs Code.:

Synonyms:6-(3-amino-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)-N-hydroxyhex-5-ynamide hydrochloride

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Chemical Property of 6-(3-amino-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)-N-hydroxyhex-5-ynamide hydrochloride

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Technology Process of 6-(3-amino-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)-N-hydroxyhex-5-ynamide hydrochloride

There total 7 articles about 6-(3-amino-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)-N-hydroxyhex-5-ynamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1449305-71-8
t-butyl N-{7-[5-(hydroxycarbamoyl)pent-1-yn-1-yl]-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl}carbamate

: 1449305-72-9
6-(3-amino-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)-N-hydroxyhex-5-ynamide hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.05.017

Reference yield:

: 1300090-04-3
benzyl N-(7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

: 1449305-72-9
6-(3-amino-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)-N-hydroxyhex-5-ynamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 0 °C / Inert atmosphere

1.2: 1.5 h / 0 °C / Inert atmosphere

2.1: hydrogen bromide / acetic acid / 2 h / 20 °C / Inert atmosphere

3.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 30 h / 55 °C / Inert atmosphere

5.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

5.2: 0.5 h / 20 °C / Inert atmosphere

6.1: hydrogenchloride / ethyl acetate / 24 h / 20 °C / Inert atmosphere

With hydrogenchloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; chloroformic acid ethyl ester; sodium hydride; triethylamine; In tetrahydrofuran; acetic acid; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.ejmech.2013.05.017

Reference yield:

: 1449305-67-2
benzyl N-(7-iodo-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

: 1449305-72-9
6-(3-amino-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)-N-hydroxyhex-5-ynamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen bromide / acetic acid / 2 h / 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 30 h / 55 °C / Inert atmosphere

4.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

4.2: 0.5 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / ethyl acetate / 24 h / 20 °C / Inert atmosphere

With hydrogenchloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; acetic acid; ethyl acetate;
DOI:10.1016/j.ejmech.2013.05.017