t-butyl N-(7-iodo-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

Base Information

Chemical Name:t-butyl N-(7-iodo-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate
CAS No.:1449305-69-4
Molecular Formula:C₂₁H₂₂IN₃O₃
Molecular Weight:491.328
Hs Code.:

Synonyms:t-butyl N-(7-iodo-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

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Chemical Property of t-butyl N-(7-iodo-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

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Technology Process of t-butyl N-(7-iodo-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

There total 4 articles about t-butyl N-(7-iodo-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1449305-68-3
3-amino-7-iodo-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one

: 1449305-69-4
t-butyl N-(7-iodo-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.05.017

Reference yield:

: 1300090-04-3
benzyl N-(7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

: 1449305-69-4
t-butyl N-(7-iodo-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 0 °C / Inert atmosphere

1.2: 1.5 h / 0 °C / Inert atmosphere

2.1: hydrogen bromide / acetic acid / 2 h / 20 °C / Inert atmosphere

3.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With hydrogen bromide; sodium hydride; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.ejmech.2013.05.017

Reference yield:

: 1449305-67-2
benzyl N-(7-iodo-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

: 1449305-69-4
t-butyl N-(7-iodo-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide / acetic acid / 2 h / 20 °C / Inert atmosphere

2: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With hydrogen bromide; In tetrahydrofuran; acetic acid;
DOI:10.1016/j.ejmech.2013.05.017