benzyl N-(7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

Base Information

Chemical Name:benzyl N-(7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate
CAS No.:1300090-04-3
Molecular Formula:C₂₃H₁₈IN₃O₃
Molecular Weight:511.319
Hs Code.:

Synonyms:benzyl N-(7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

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Chemical Property of benzyl N-(7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

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Technology Process of benzyl N-(7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

There total 6 articles about benzyl N-(7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.5%

: 124676-19-3
2-(benzotriazol-1-yl)-N-(benzyloxycarbonyl)glycine

: 51073-69-9
(2-amino-5-iodophenyl)(phenyl)methanone

: 1300090-04-3
benzyl N-(7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

Guidance literature:: 2-(benzotriazol-1-yl)-N-(benzyloxycarbonyl)glycine; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; at 0 ℃; for 3.5h; Inert atmosphere;

(2-amino-5-iodophenyl)(phenyl)methanone; With 4-methyl-morpholine; In tetrahydrofuran; dichloromethane; at 20 ℃; Inert atmosphere;

With ammonia; In methanol; for 0.75h;
DOI:10.1016/j.ejmech.2013.05.017

Reference yield:

: 1300090-39-4
phenylmethyl (1-amino-2-{[4-iodo-2-(phenylcarbonyl)phenyl]amino}-2-oxoethyl)carbamate

: 1300090-04-3
benzyl N-(7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

Guidance literature:: With ammonium acetate; acetic acid; at 20 ℃; for 3h;

Reference yield:

: 2835-77-0
(2-aminophenyl)(phenyl)methanone

: 1300090-04-3
benzyl N-(7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Iodine monochloride / dichloromethane / -70 - 20 °C

2.1: N,N-dimethyl-formamide; oxalyl dichloride / tetrahydrofuran / 3 h / 0 °C

2.2: 0 - 20 °C

2.3: 1 h / 0 °C

3.1: ammonium acetate; acetic acid / 3 h / 20 °C

With oxalyl dichloride; ammonium acetate; Iodine monochloride; acetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;