3-amino-7-iodo-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Base Information

Chemical Name:3-amino-7-iodo-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
CAS No.:1449305-68-3
Molecular Formula:C₁₆H₁₄IN₃O
Molecular Weight:391.211
Hs Code.:

Synonyms:3-amino-7-iodo-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-amino-7-iodo-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one

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Technology Process of 3-amino-7-iodo-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one

There total 3 articles about 3-amino-7-iodo-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1449305-67-2
benzyl N-(7-iodo-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

: 1449305-68-3
3-amino-7-iodo-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Guidance literature:: With hydrogen bromide; In acetic acid; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.05.017

Reference yield:

: 1300090-04-3
benzyl N-(7-iodo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamate

: 1449305-68-3
3-amino-7-iodo-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 0 °C / Inert atmosphere

1.2: 1.5 h / 0 °C / Inert atmosphere

2.1: hydrogen bromide / acetic acid / 2 h / 20 °C / Inert atmosphere

With hydrogen bromide; sodium hydride; In acetic acid; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.ejmech.2013.05.017

Reference yield:

: 51073-69-9
(2-amino-5-iodophenyl)(phenyl)methanone

: 1449305-68-3
3-amino-7-iodo-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran; dichloromethane / 3.5 h / 0 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

1.3: 0.75 h

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 0 °C / Inert atmosphere

2.2: 1.5 h / 0 °C / Inert atmosphere

3.1: hydrogen bromide / acetic acid / 2 h / 20 °C / Inert atmosphere

With oxalyl dichloride; hydrogen bromide; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.ejmech.2013.05.017