5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(pyrimidin-4-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

Base Information

Chemical Name:5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(pyrimidin-4-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide
CAS No.:1454666-76-2
Molecular Formula:C₂₀H₁₆BrF₃N₄O₂S
Molecular Weight:513.338
Hs Code.:

Synonyms:5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(pyrimidin-4-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

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Chemical Property of 5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(pyrimidin-4-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

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Technology Process of 5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(pyrimidin-4-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

There total 6 articles about 5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(pyrimidin-4-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 163133-86-6,163133-87-7,176772-96-6,176773-06-1,176773-07-2,176799-58-9,591-54-8
pyrimidin-4-amine

: 1454667-86-7
5-(2-bromo-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonyl chloride

: 1454666-76-2
5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(pyrimidin-4-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

Guidance literature:: With pyridine; In chloroform; at 50 ℃;

Reference yield:

: 481075-58-5
2-bromo-1-iodo-4-(trifluoromethyl)benzene

: 1454666-76-2
5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(pyrimidin-4-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / water; 1,4-dioxane / 100 °C

1.2: 3 h / 130 °C / Microwave irradiation

2.1: methanol; acetyl chloride / tetrahydrofuran / 0 °C

3.1: triethylamine; sulfuryl dichloride / dichloromethane / 2 h / Cooling with ice

4.1: pyridine / chloroform / 50 °C

With pyridine; methanol; sulfuryl dichloride; potassium carbonate; triethylamine; acetyl chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; water;

Reference yield:

: 1454667-10-7
tert-butyl 5-(2-bromo-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1454666-76-2
5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(pyrimidin-4-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; acetyl chloride / tetrahydrofuran / 0 °C

2: triethylamine; sulfuryl dichloride / dichloromethane / 2 h / Cooling with ice

3: pyridine / chloroform / 50 °C

With pyridine; methanol; sulfuryl dichloride; triethylamine; acetyl chloride; In tetrahydrofuran; dichloromethane; chloroform;