5-(2-bromo-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonyl chloride

Base Information

Chemical Name:5-(2-bromo-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonyl chloride
CAS No.:1454667-86-7
Molecular Formula:C₁₆H₁₂BrClF₃NO₂S
Molecular Weight:454.695
Hs Code.:

Synonyms:5-(2-bromo-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonyl chloride

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Chemical Property of 5-(2-bromo-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonyl chloride

Chemical Property:

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Technology Process of 5-(2-bromo-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonyl chloride

There total 5 articles about 5-(2-bromo-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454667-12-9
5-(2-bromo-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 1454667-86-7
5-(2-bromo-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonyl chloride

Guidance literature:: With sulfuryl dichloride; triethylamine; In dichloromethane; for 2h; Cooling with ice;

Reference yield:

: 481075-58-5
2-bromo-1-iodo-4-(trifluoromethyl)benzene

: 1454667-86-7
5-(2-bromo-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / water; 1,4-dioxane / 100 °C

1.2: 3 h / 130 °C / Microwave irradiation

2.1: methanol; acetyl chloride / tetrahydrofuran / 0 °C

3.1: triethylamine; sulfuryl dichloride / dichloromethane / 2 h / Cooling with ice

With methanol; sulfuryl dichloride; potassium carbonate; triethylamine; acetyl chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1454667-10-7
tert-butyl 5-(2-bromo-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1454667-86-7
5-(2-bromo-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; acetyl chloride / tetrahydrofuran / 0 °C

2: triethylamine; sulfuryl dichloride / dichloromethane / 2 h / Cooling with ice

With methanol; sulfuryl dichloride; triethylamine; acetyl chloride; In tetrahydrofuran; dichloromethane;