1-tert-butyl 4-ethyl 4-[(1-trityl-1H-imidazol-4-yl)methyl]piperidine-1,4-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 4-ethyl 4-[(1-trityl-1H-imidazol-4-yl)methyl]piperidine-1,4-dicarboxylate
CAS No.:1192189-81-3
Molecular Formula:C₃₆H₄₁N₃O₄
Molecular Weight:579.739
Hs Code.:

Synonyms:1-tert-butyl 4-ethyl 4-[(1-trityl-1H-imidazol-4-yl)methyl]piperidine-1,4-dicarboxylate

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Chemical Property of 1-tert-butyl 4-ethyl 4-[(1-trityl-1H-imidazol-4-yl)methyl]piperidine-1,4-dicarboxylate

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Technology Process of 1-tert-butyl 4-ethyl 4-[(1-trityl-1H-imidazol-4-yl)methyl]piperidine-1,4-dicarboxylate

There total 1 articles about 1-tert-butyl 4-ethyl 4-[(1-trityl-1H-imidazol-4-yl)methyl]piperidine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 103057-10-9
4-chloromethyl-1-tritylimidazole

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 1192189-81-3
1-tert-butyl 4-ethyl 4-[(1-trityl-1H-imidazol-4-yl)methyl]piperidine-1,4-dicarboxylate

Guidance literature:: 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1.16667h;

4-chloromethyl-1-tritylimidazole; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield: 86.0%

: 1192189-81-3
1-tert-butyl 4-ethyl 4-[(1-trityl-1H-imidazol-4-yl)methyl]piperidine-1,4-dicarboxylate

: 1192189-82-4
1-(tert-butoxycarbonyl)-4-[(1-trityl-1H-imidazol-4-yl)methyl]piperidine-4-carboxylic acid

Guidance literature:: 1-tert-butyl 4-ethyl 4-[(1-trityl-1H-imidazol-4-yl)methyl]piperidine-1,4-dicarboxylate; With water; lithium hydroxide; In tetrahydrofuran; methanol; Reflux;

With sodium hydrogen sulfate; In water; pH=5 - 6;

Reference yield:

: 1192189-81-3
1-tert-butyl 4-ethyl 4-[(1-trityl-1H-imidazol-4-yl)methyl]piperidine-1,4-dicarboxylate

: 1192189-83-5
tert-butyl 4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]-4-[(1-trityl-1H-imidazol-4-yl)methyl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide; water / tetrahydrofuran; methanol / Inert atmosphere; Reflux

1.2: pH 5 - 6

2.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / Isopropyl acetate / 0.08 h / Inert atmosphere

2.2: 2 h / 90 °C / Inert atmosphere

With water; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; methanol; Isopropyl acetate;
DOI:10.1021/ml500367g