N-{3-[3-(2-benzyloxy-pyridin-3-yl)-5-tert-butyl-phenyl]-1-oxo-isochroman-7-yl}-methanesulfonamide

Base Information

Chemical Name:N-{3-[3-(2-benzyloxy-pyridin-3-yl)-5-tert-butyl-phenyl]-1-oxo-isochroman-7-yl}-methanesulfonamide
CAS No.:1206776-66-0
Molecular Formula:C₃₂H₃₂N₂O₅S
Molecular Weight:556.682
Hs Code.:

Synonyms:N-{3-[3-(2-benzyloxy-pyridin-3-yl)-5-tert-butyl-phenyl]-1-oxo-isochroman-7-yl}-methanesulfonamide

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Chemical Property of N-{3-[3-(2-benzyloxy-pyridin-3-yl)-5-tert-butyl-phenyl]-1-oxo-isochroman-7-yl}-methanesulfonamide

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Technology Process of N-{3-[3-(2-benzyloxy-pyridin-3-yl)-5-tert-butyl-phenyl]-1-oxo-isochroman-7-yl}-methanesulfonamide

There total 16 articles about N-{3-[3-(2-benzyloxy-pyridin-3-yl)-5-tert-butyl-phenyl]-1-oxo-isochroman-7-yl}-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1256489-09-4
C₃₃H₃₆N₂O₇S

: 1206776-66-0
N-{3-[3-(2-benzyloxy-pyridin-3-yl)-5-tert-butyl-phenyl]-1-oxo-isochroman-7-yl}-methanesulfonamide

: 1256488-45-5
N-{3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-1-oxo-isochroman-7-yl}-methanesulfonamide

Guidance literature:: With acetic anhydride; at 100 ℃; for 2h;

Reference yield:

: 52200-49-4
3-bromo-2-(phenylmethoxy)pyridine

: 1206776-66-0
N-{3-[3-(2-benzyloxy-pyridin-3-yl)-5-tert-butyl-phenyl]-1-oxo-isochroman-7-yl}-methanesulfonamide

: 1256488-45-5
N-{3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-1-oxo-isochroman-7-yl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium acetate; bis(pinacol)diborane / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 26 h / 70 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; dichloromethane / 0.5 h / 100 °C / Sealed tube; Microwave Irradiation

3: potassium hydroxide / ethanol / 1.5 h / Reflux

4: sodium tetrahydroborate / ethanol / 4 h

5: acetic anhydride / 2 h / 100 °C

With sodium tetrahydroborate; potassium acetate; acetic anhydride; sodium carbonate; bis(pinacol)diborane; potassium hydroxide; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane;

Reference yield:

: 1072952-41-0
(2-benzyloxy-3-pyridyl)boronic acid

: 1206776-66-0
N-{3-[3-(2-benzyloxy-pyridin-3-yl)-5-tert-butyl-phenyl]-1-oxo-isochroman-7-yl}-methanesulfonamide

: 1256488-45-5
N-{3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-1-oxo-isochroman-7-yl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; dichloromethane / 0.5 h / 100 °C / Sealed tube; Microwave Irradiation

2: potassium hydroxide / ethanol / 1.5 h / Reflux

3: sodium tetrahydroborate / ethanol / 4 h

4: acetic anhydride / 2 h / 100 °C

With sodium tetrahydroborate; acetic anhydride; sodium carbonate; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; dichloromethane;