4-[2-(4-bromophenyl)-2-methoxycarbonylethyl]benzoic acid tert-butyl ester

Base Information

Chemical Name:4-[2-(4-bromophenyl)-2-methoxycarbonylethyl]benzoic acid tert-butyl ester
CAS No.:1207989-81-8
Molecular Formula:C₂₁H₂₃BrO₄
Molecular Weight:419.315
Hs Code.:

Synonyms:4-[2-(4-bromophenyl)-2-methoxycarbonylethyl]benzoic acid tert-butyl ester

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Chemical Property of 4-[2-(4-bromophenyl)-2-methoxycarbonylethyl]benzoic acid tert-butyl ester

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Technology Process of 4-[2-(4-bromophenyl)-2-methoxycarbonylethyl]benzoic acid tert-butyl ester

There total 4 articles about 4-[2-(4-bromophenyl)-2-methoxycarbonylethyl]benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1207989-76-1
4-iodomethylbenzoic acid tert-butyl ester

: 41841-16-1
(4-bromo-phenyl)-acetic acid methyl ester

: 1207989-81-8
4-[2-(4-bromophenyl)-2-methoxycarbonylethyl]benzoic acid tert-butyl ester

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -8 - -2 ℃;

Reference yield:

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 1207989-81-8
4-[2-(4-bromophenyl)-2-methoxycarbonylethyl]benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / 2 h / Reflux

2: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -8 - -2 °C

With sulfuric acid; lithium hexamethyldisilazane; In tetrahydrofuran;

Reference yield:

: 1642-81-5
p-(chloromethyl)benzoic acid

: 1207989-81-8
4-[2-(4-bromophenyl)-2-methoxycarbonylethyl]benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 24.5 h / 20 °C

1.2: 1 h / -5 - 10 °C

2.1: sodium iodide / acetone / 2 h / Reflux

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -8 - -2 °C

With oxalyl dichloride; sodium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;