(R)-2-(4-bromophenyl)-3-(4-tert-butoxycarbonylphenyl)propionate (S)-2-hydroxymethyl pyrrolidinium

Base Information

Chemical Name:(R)-2-(4-bromophenyl)-3-(4-tert-butoxycarbonylphenyl)propionate (S)-2-hydroxymethyl pyrrolidinium
CAS No.:1207989-85-2
Molecular Formula:C₅H₁₁NO*C₂₀H₂₁BrO₄
Molecular Weight:506.437
Hs Code.:
Mol file:1207989-85-2.mol

Synonyms:(R)-2-(4-bromophenyl)-3-(4-tert-butoxycarbonylphenyl)propionate (S)-2-hydroxymethyl pyrrolidinium

Suppliers and Price of (R)-2-(4-bromophenyl)-3-(4-tert-butoxycarbonylphenyl)propionate (S)-2-hydroxymethyl pyrrolidinium

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (R)-2-(4-bromophenyl)-3-(4-tert-butoxycarbonylphenyl)propionate (S)-2-hydroxymethyl pyrrolidinium

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (R)-2-(4-bromophenyl)-3-(4-tert-butoxycarbonylphenyl)propionate (S)-2-hydroxymethyl pyrrolidinium

There total 6 articles about (R)-2-(4-bromophenyl)-3-(4-tert-butoxycarbonylphenyl)propionate (S)-2-hydroxymethyl pyrrolidinium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1207989-81-8
4-[2-(4-bromophenyl)-2-methoxycarbonylethyl]benzoic acid tert-butyl ester

: 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol

: 1207989-85-2
(R)-2-(4-bromophenyl)-3-(4-tert-butoxycarbonylphenyl)propionate (S)-2-hydroxymethyl pyrrolidinium

Guidance literature:: 4-[2-(4-bromophenyl)-2-methoxycarbonylethyl]benzoic acid tert-butyl ester; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 45 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate; at 32 ℃;

(S)-1-Pyrrolidin-2-yl-methanol; In ethyl acetate; at 68 ℃;

Reference yield:

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 1207989-85-2
(R)-2-(4-bromophenyl)-3-(4-tert-butoxycarbonylphenyl)propionate (S)-2-hydroxymethyl pyrrolidinium

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 2 h / Reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -8 - -2 °C

3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 1 h / 45 °C

3.2: 68 °C

With lithium hydroxide monohydrate; sulfuric acid; lithium hexamethyldisilazane; In tetrahydrofuran; water;

Reference yield:

: 1642-81-5
p-(chloromethyl)benzoic acid

: 1207989-85-2
(R)-2-(4-bromophenyl)-3-(4-tert-butoxycarbonylphenyl)propionate (S)-2-hydroxymethyl pyrrolidinium

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 24.5 h / 20 °C

1.2: 1 h / -5 - 10 °C

2.1: sodium iodide / acetone / 2 h / Reflux

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -8 - -2 °C

4.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 1 h / 45 °C

4.2: 68 °C

With oxalyl dichloride; lithium hydroxide monohydrate; sodium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;