N₁-(4'-cyanophenyl)-5-(4''-(2-cyanovinyl)-2'',6''-dimethylphenoxy)-4-carboxy-2-nitroaniline

Base Information

• Chemical Name: N₁-(4'-cyanophenyl)-5-(4''-(2-cyanovinyl)-2'',6''-dimethylphenoxy)-4-carboxy-2-nitroaniline
• CAS No.: 1372406-98-8
• Molecular Formula: C₂₅H₁₈N₄O₅
• Molecular Weight: 454.442

Synonyms:N₁-(4'-cyanophenyl)-5-(4''-(2-cyanovinyl)-2'',6''-dimethylphenoxy)-4-carboxy-2-nitroaniline

Chemical Property of N₁-(4'-cyanophenyl)-5-(4''-(2-cyanovinyl)-2'',6''-dimethylphenoxy)-4-carboxy-2-nitroaniline

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N₁-(4'-cyanophenyl)-5-(4''-(2-cyanovinyl)-2'',6''-dimethylphenoxy)-4-carboxy-2-nitroaniline

There total 7 articles about N₁-(4'-cyanophenyl)-5-(4''-(2-cyanovinyl)-2'',6''-dimethylphenoxy)-4-carboxy-2-nitroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N1-(4'-cyanophenyl)-5-(4''-(2-cyanovinyl)-2'',6''-dimethylphenoxy)-4-methoxycarbonyl-2-nitroaniline (1372406-97-7) → N1-(4'-cyanophenyl)-5-(4''-(2-cyanovinyl)-2'',6''-dimethylphenoxy)-4-carboxy-2-nitroaniline (1372406-98-8)

Guidance literature:

N₁-(4'-cyanophenyl)-5-(4''-(2-cyanovinyl)-2'',6''-dimethylphenoxy)-4-methoxycarbonyl-2-nitroaniline; With sodium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 4h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=2 - 3;

DOI:10.1021/jm3007678

Reference yield:

methanol (67-56-1) + N1-(4'-cyanophenyl)-5-(4''-(2-cyanovinyl)-2'',6''-dimethylphenoxy)-4-methoxycarbonyl-2-nitroaniline (1372406-97-7) → N1-(4'-cyanophenyl)-5-(4''-(2-cyanovinyl)-2'',6''-dimethylphenoxy)-4-carboxy-2-nitroaniline (1372406-98-8)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2017.04.068

Reference yield:

5-chloro-N1-(4-cyanophenyl)-4-methoxycarbonyl-2-nitroaniline (1372129-84-4) → N1-(4'-cyanophenyl)-5-(4''-(2-cyanovinyl)-2'',6''-dimethylphenoxy)-4-carboxy-2-nitroaniline (1372406-98-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 190 °C / Microwave irradiation

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C

2.2: 3 h / 20 °C

3.1: sodium hydroxide / tetrahydrofuran; water; methanol / 4 h / 20 °C

3.2: pH 2 - 3

With potassium tert-butylate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm3007678

upstream raw materials:

5-chloro-N¹-(4-cyanophenyl)-4-methoxycarbonyl-2-nitroaniline

N₁-(4'-cyanophenyl)-5-(2'',6''-dimethyl-4''-formylphenoxy)-4-methoxycarbonyl-2-nitroaniline

N₁-(4'-cyanophenyl)-5-(4''-(2-cyanovinyl)-2'',6''-dimethylphenoxy)-4-methoxycarbonyl-2-nitroaniline

2,4 dichlorobenzoic acid

Downstream raw materials:

N₁-(4'-cyanophenyl)-5-(4''-(2-cyanovinyl)-2'',6''-dimethylphenoxy)-4-carbamoyl-2-nitroaniline

N₁-(4'-cyanophenyl)-5-(4''-(2-cyanovinyl)-2'',6''-dimethylphenoxy)-4-methylcarbamoyl-2-nitroaniline

C₂₅H₂₁N₅O₂

C₂₆H₂₃N₅O₂

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