Panthenol

Base Information

• Chemical Name: Panthenol
• CAS No.: 16485-10-2
• Deprecated CAS: 62507-76-0
• Molecular Formula: C₉H₁₉NO₄
• Molecular Weight: 205.254
• Hs Code.: 29362400
• European Community (EC) Number: 240-540-6
• NSC Number: 759899,759127,302962
• UNII: WV9CM0O67Z
• DSSTox Substance ID: DTXSID3044598
• Nikkaji Number: J321.113D
• Wikipedia: Panthenol
• Wikidata: Q196473
• NCI Thesaurus Code: C82290
• RXCUI: 1044977
• Metabolomics Workbench ID: 123387
• ChEMBL ID: CHEMBL1371937
• Mol file: 16485-10-2.mol

Synonyms:(+)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide;2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide;Bepanthen;butanamide, 2,4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-, (+--)-;Corneregel;D-panthenol;dexpanthenol;Dexpanthenol Heumann;DL-panthenol;Ilopan;Marolderm;NasenSpray ratiopharm Panthenol;Nasicur;Otriven Dexpanthenol;Pan Rhinol;Pan-Ophtal;panthenol;Panthenol Braun;Panthenol Jenapharm;Panthenol LAW;Panthenol Lichtenstein;panthenol von ct;Panthenol-ratiopharm;Panthoderm;Panthogenat;pantothenol;Repa-Ophtal;Rhinoclir;Siozwo SANA;Ucee D;Urupan;Wund- und Heilsalbe LAW

Chemical Property of Panthenol

Chemical Property:

• Appearance/Colour: white crystalline powder or light yellow liquid
• Vapor Pressure: 2.21E-11mmHg at 25°C
• Melting Point: 66-69 °C(lit.)
• Refractive Index: 1.501
• Boiling Point: 483.6 °C at 760 mmHg
• PKA: 13.03±0.20(Predicted)
• Flash Point: 246.3 °C
• PSA: 89.79000
• Density: 1.166 g/cm³
• LogP: -0.74470
• Storage Temp.: −20°C
• Sensitive.: Hygroscopic
• Solubility.: Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: Soluble in water, ethanol, ether, chloroform, and propylene glycol.
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 205.13140809
• Heavy Atom Count: 14
• Complexity: 182

Purity/Quality:

99% ^*data from raw suppliers

DL-Panthenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-48-41-37/38-20/21/22
• Safety Statements: 26-37-45-36/37/39-22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)(CO)C(C(=O)NCCCO)O
• Recent ClinicalTrials: Efficacy of Nasal Naphazoline Hydrocloride + Pheniramine Maleate + Panthenol Compared With Naphazoline Hydrocloride in the Symptomatic Control of Nasal Congestion and Nasopharyngeal
• Uses: Panthenol, the active form of panthenol, is enzymatically cleaved to form pantothenic acid (Vitamin B5), which is an essential component of Coenzyme A that acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium. Due to its good penetration and high local concentrations, dexpanthanol is used in many topical products, such as ointments and lotions for treatment of dermatological conditions to relieve itching or promote healing. Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing. Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties. The vitamin ingredient Panthenol is valued in skin and hair care applications for its moisturizing properties. It has anti-inflammatory effects and soothes irritated and sensitive skin. For hair care application it is known for its humectant properties and its ability to improve the resistance of hair to mechanical stress. vitamin B5 precursor, radioprotectant, antimalarial panthenol (pro-vitamin B5) acts as a penetrating moisturizer. Panthenol appears to stimulate cellular proliferation and aid in tissue repair. Studies indicate that when topically applied, panthenol penetrates the skin and gets converted into pantothenic acid, a B complex vitamin. Such action could possibly influence the skin’s natural resources of pantothenic acid. It imparts a nonirritant, non-sensitizing, moisturizing, and conditioning feel and promotes normal keratinization and wound-healing. Panthenol protects the skin against sunburn, provides relief for existing sunburn, and enhances the natural tanning process. Panthenol’s humectant character enables it to hold water in the product or attract water from the environment, resulting in a moisturizing effect. It enhances skin suppleness, and claims are that it also acts as an anti-inflammatory agent. It is considered a non-comedogenic raw material. DL-Panthenol is used in the topical treatment of skin disorders, such as minor irritations and skin burns. Also used in the strengthening and treatment of hair.

Technology Process of Panthenol

There total 2 articles about Panthenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propan-1-ol-3-amine (156-87-6) + pantolactone (79-50-5) → panthenol (50584-68-4,16485-10-2,1113-70-8)

Guidance literature:

at 110 ℃;

Reference yield:

→ panthenol (50584-68-4,16485-10-2,1113-70-8)

Guidance literature:

Reference yield:

panthenol (50584-68-4,16485-10-2,1113-70-8) → dexpanthenol (74561-18-5,1113-70-8) + pantothenol (81-13-0,1113-70-8)

Guidance literature:

With LUX i-Amylose-1; In ethanol; hexane; at 25 ℃; Temperature; Resolution of racemate;

DOI:10.1002/chir.23152

upstream raw materials:

propan-1-ol-3-amine

pantolactone

Downstream raw materials:

Panthenol-triacetat

C₁₁H₂₁NO₅

C₁₃H₂₃NO₆

dexpanthenol

Refernces