2-[[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]methoxy]-N-[1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]acetamide

Base Information

Chemical Name:2-[[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]methoxy]-N-[1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]acetamide
CAS No.:1242847-60-4
Molecular Formula:C₃₀H₃₆F₃N₅O₅S
Molecular Weight:635.708
Hs Code.:

2-[[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]methoxy]-N-[1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]acetamide

Synonyms:2-[[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]methoxy]-N-[1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]acetamide

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Chemical Property of 2-[[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]methoxy]-N-[1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]acetamide

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Technology Process of 2-[[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]methoxy]-N-[1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]acetamide

There total 8 articles about 2-[[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]methoxy]-N-[1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1197230-76-4
5'-trifluoromethyl-3,4,5,6-tetrahydro-2H[1,2']bipyridinyl-4-yl-ammonium chloride

: 1242850-00-5
2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid

: 1242847-60-4
2-[[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]methoxy]-N-[1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]acetamide

Guidance literature:: 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

5'-trifluoromethyl-3,4,5,6-tetrahydro-2H[1,2']bipyridinyl-4-yl-ammonium chloride; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 73627-16-4
N-[2-(1H-pyrrol-1-yl)ethyl]acetamide

: 1242847-60-4
2-[[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]methoxy]-N-[1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: water; potassium hydroxide / Reflux

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: trifluoroacetic acid / 20 °C / Cooling with ice

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

5.1: triethylamine / dichloromethane / 0 °C

6.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

6.2: 0 - 20 °C

7.1: water; potassium hydroxide / ethanol / 16 h / 20 °C

7.2: pH 3

8.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

8.2: 0 - 20 °C

With lithium aluminium tetrahydride; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 874-63-5
3,5-dimethylmethoxybenzene

: 1242847-60-4
2-[[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]methoxy]-N-[1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: chlorosulfonic acid / dichloromethane / 0.17 h / 0 °C

2.1: triethylamine / dichloromethane / 0 °C

3.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

3.2: 0 - 20 °C

4.1: water; potassium hydroxide / ethanol / 16 h / 20 °C

4.2: pH 3

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

5.2: 0 - 20 °C

With chlorosulfonic acid; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;