methyl 3-<2-(2-benzyloxy-4,6-dichlorophenyl)ethyl>-4,5-dihydroisoxazol-5-yl acetate

Base Information

Chemical Name:methyl 3-<2-(2-benzyloxy-4,6-dichlorophenyl)ethyl>-4,5-dihydroisoxazol-5-yl acetate
CAS No.:124082-14-0
Molecular Formula:C₂₁H₂₁Cl₂NO₄
Molecular Weight:422.308
Hs Code.:

Synonyms:methyl 3-<2-(2-benzyloxy-4,6-dichlorophenyl)ethyl>-4,5-dihydroisoxazol-5-yl acetate

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Chemical Property of methyl 3-<2-(2-benzyloxy-4,6-dichlorophenyl)ethyl>-4,5-dihydroisoxazol-5-yl acetate

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Technology Process of methyl 3-<2-(2-benzyloxy-4,6-dichlorophenyl)ethyl>-4,5-dihydroisoxazol-5-yl acetate

There total 10 articles about methyl 3-<2-(2-benzyloxy-4,6-dichlorophenyl)ethyl>-4,5-dihydroisoxazol-5-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 67-56-1
methanol

: 124082-13-9
<3-<2-(2-benzyloxy-4,6-dichlorophenyl)ethyl>-4,5-dihydroisoxazol-5-yl>acetonitrile

: 124082-14-0
methyl 3-<2-(2-benzyloxy-4,6-dichlorophenyl)ethyl>-4,5-dihydroisoxazol-5-yl acetate

Guidance literature:: With hydrogenchloride; In methanol; diethyl ether; for 18h; Ambient temperature;

Reference yield:

: 591-35-5
3,5-dichlorophenol

: 124082-14-0
methyl 3-<2-(2-benzyloxy-4,6-dichlorophenyl)ethyl>-4,5-dihydroisoxazol-5-yl acetate

Guidance literature:: Multi-step reaction with 9 steps

1: K₂CO₃ / acetone / 4 h / Heating

2: 97 percent / N,N-diethylaniline / 12 h / Heating

3: 79 percent / K₂CO₃ / dimethylformamide / 8 h / Heating

4: 1.) borane-THF complex, 2.) 3M aq. NaOH, 30percent v/v H₂O₂ / 1.) THF, 6 deg C -> room temperature, 2 h, 2.) H₂O, 50 deg C, 1 h

5: 98 percent / pyridinium chlorochromate, sodium acetate / CH₂Cl₂ / 1.) 10 deg C, 1 h, 2.) room temperature, 1 h

6: 59 percent / NaOMe, NH₂OH*HCl / methanol / 0.5 h / Ambient temperature

7: N-chlorosuccinimide, pyridine / CHCl₃ / 1 h / Ambient temperature

8: Et₃N / CHCl₃ / 0.75 h / 45 °C

9: 69 percent / dry hydrogen chloride / diethyl ether; methanol / 18 h / Ambient temperature

With pyridine; hydrogenchloride; sodium hydroxide; N-chloro-succinimide; borane-THF; hydroxylamine hydrochloride; dihydrogen peroxide; sodium methylate; sodium acetate; potassium carbonate; triethylamine; pyridinium chlorochromate; N,N-diethylaniline; In methanol; diethyl ether; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone;

Reference yield:

: 100-39-0
benzyl bromide

: 124082-14-0
methyl 3-<2-(2-benzyloxy-4,6-dichlorophenyl)ethyl>-4,5-dihydroisoxazol-5-yl acetate

Guidance literature:: Multi-step reaction with 7 steps

1: 79 percent / K₂CO₃ / dimethylformamide / 8 h / Heating

2: 1.) borane-THF complex, 2.) 3M aq. NaOH, 30percent v/v H₂O₂ / 1.) THF, 6 deg C -> room temperature, 2 h, 2.) H₂O, 50 deg C, 1 h

3: 98 percent / pyridinium chlorochromate, sodium acetate / CH₂Cl₂ / 1.) 10 deg C, 1 h, 2.) room temperature, 1 h

4: 59 percent / NaOMe, NH₂OH*HCl / methanol / 0.5 h / Ambient temperature

5: N-chlorosuccinimide, pyridine / CHCl₃ / 1 h / Ambient temperature

6: Et₃N / CHCl₃ / 0.75 h / 45 °C

7: 69 percent / dry hydrogen chloride / diethyl ether; methanol / 18 h / Ambient temperature

With pyridine; hydrogenchloride; sodium hydroxide; N-chloro-succinimide; borane-THF; hydroxylamine hydrochloride; dihydrogen peroxide; sodium methylate; sodium acetate; potassium carbonate; triethylamine; pyridinium chlorochromate; In methanol; diethyl ether; dichloromethane; chloroform; N,N-dimethyl-formamide;