C₄₂H₄₇N₄O₁₄P

Base Information

• Chemical Name: C₄₂H₄₇N₄O₁₄P
• CAS No.: 87007-52-1
• Molecular Formula: C₄₂H₄₇N₄O₁₄P
• Molecular Weight: 862.827
• Mol file: 87007-52-1.mol

Synonyms:C₄₂H₄₇N₄O₁₄P

Chemical Property of C₄₂H₄₇N₄O₁₄P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of C₄₂H₄₇N₄O₁₄P

There total 12 articles about C₄₂H₄₇N₄O₁₄P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-dithymidylyl-3',5'-O-methylphosphate (130856-82-5) → C42H47N4O14P (87007-52-1)

Guidance literature:

With tert-butylamine; In methanol; 1.) -20 deg C, 12 h, 2.) -20 deg C -> room temperature, 5 h;

DOI:10.1080/15257779408011881

Reference yield:

C48H61N4O14PSi → C42H47N4O14P (87007-52-1)

Guidance literature:

With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.1021/ja00256a030

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → C42H47N4O14P (87007-52-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 4 h / Ambient temperature

2: Bu₄NF, AcOH / tetrahydrofuran / 24 h / Ambient temperature

With pyridine; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran;

DOI:10.1021/ja00256a030

upstream raw materials:

3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-dithymidylyl-3',5'-O-methylphosphate

methyl 5'-O-dimethoxytrityl-N³-benzoylthymidin-3'-yl N³,3'-O-dibenzoylthymidin-5'-yl phosphate

methylphosphonic acid dichloroanhydride

3'-O-levulinoylthymidine

Downstream raw materials:

C₅₁H₅₇N₅O₁₉P₂

5'-O-(4-4'-dimethoxytrityl)thymidine

thymidine

C₃₀H₃₉N₅O₁₇P₂