Technology Process of (2S,3S)-1,2-epoxy-5-(4-methoxybenzyloxy)-3-pentanol
There total 3 articles about (2S,3S)-1,2-epoxy-5-(4-methoxybenzyloxy)-3-pentanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
tetrahydrofuran;
at 0 ℃;
for 1.5h;
DOI:10.1021/jo201729t
- Guidance literature:
-
Multi-step reaction with 2 steps
1: osmium(VIII) oxide; methanesulfonamide; sodium hydrogencarbonate; potassium carbonate; hydroquinine (anthraquinone-1,4-diyl) diether; potassium hexacyanoferrate(III) / water; tert-butyl alcohol / 14 h / 0 °C
2: sodium hydroxide / tetrahydrofuran / 1.5 h / 0 °C
With
osmium(VIII) oxide; methanesulfonamide; sodium hydrogencarbonate; potassium carbonate; hydroquinine (anthraquinone-1,4-diyl) diether; sodium hydroxide; potassium hexacyanoferrate(III);
In
tetrahydrofuran; water; tert-butyl alcohol;
1: Sharpless dihydroxylation;
DOI:10.1021/jo201729t
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N-chloro-succinimide; dimethylsulfide / dichloromethane / -20 - 20 °C
2: osmium(VIII) oxide; methanesulfonamide; sodium hydrogencarbonate; potassium carbonate; hydroquinine (anthraquinone-1,4-diyl) diether; potassium hexacyanoferrate(III) / water; tert-butyl alcohol / 14 h / 0 °C
3: sodium hydroxide / tetrahydrofuran / 1.5 h / 0 °C
With
N-chloro-succinimide; osmium(VIII) oxide; dimethylsulfide; methanesulfonamide; sodium hydrogencarbonate; potassium carbonate; hydroquinine (anthraquinone-1,4-diyl) diether; sodium hydroxide; potassium hexacyanoferrate(III);
In
tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
2: Sharpless dihydroxylation;
DOI:10.1021/jo201729t
