3-amino-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline

Base Information

• Chemical Name: 3-amino-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline
• CAS No.: 64194-96-3
• Molecular Formula: C₂₃H₂₀Cl₂N₄O₃
• Molecular Weight: 471.343
• Mol file: 64194-96-3.mol

Synonyms:3-amino-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline

Chemical Property of 3-amino-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-amino-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline

There total 4 articles about 3-amino-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-Benzyloxycarbonylamino-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester (83520-08-5) → 3-amino-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline (64194-96-3)

Guidance literature:

With hydrazine hydrate; acetic acid; In ethanol; for 2h; Heating;

DOI:10.1021/jm00354a015

Reference yield:

phenylmethyl cyanomethylcarbamate (3589-41-1) → 3-amino-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline (64194-96-3)

Guidance literature:

Multi-step reaction with 3 steps

1: HCl gas / diethyl ether / 0 °C

2: 2.) AcOH / 1.) EtOH, Rt, 22 h, 2.) benzene, reflux, 3 h

3: 77 percent / NH₂NH₂*H₂O, AcOH / ethanol / 2 h / Heating

With hydrogenchloride; hydrazine hydrate; acetic acid; In diethyl ether; ethanol;

DOI:10.1021/jm00354a015

Reference yield:

ethyl 2-benzyloxycarbonylaminoacetimidate hydrochloride (51030-44-5) → 3-amino-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline (64194-96-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) AcOH / 1.) EtOH, Rt, 22 h, 2.) benzene, reflux, 3 h

2: 77 percent / NH₂NH₂*H₂O, AcOH / ethanol / 2 h / Heating

With hydrazine hydrate; acetic acid; In ethanol;

DOI:10.1021/jm00354a015

upstream raw materials:

2-Benzyloxycarbonylamino-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester

phenylmethyl cyanomethylcarbamate

ethyl 2-benzyloxycarbonylaminoacetimidate hydrochloride

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone

Downstream raw materials:

[6-chloro-3-(2-chloro-acetylamino)-4-(2-chloro-phenyl)-4-hydroxy-3,4-dihydro-quinazolin-2-ylmethyl]-carbamic acid benzyl ester

2',5-dichloro-2-<3-<<(phthaloylglycyl)amino>methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone

2',5-dichloro-2-<3-<(α-azidoacetamido)methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone

2',5-dichloro-2-<3-<(α-chloroacetamido)methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone

Refernces