2,2,3,3-Tetrafluoro-1-propanol

Base Information

• Chemical Name: 2,2,3,3-Tetrafluoro-1-propanol
• CAS No.: 76-37-9
• Molecular Formula: C3H4F4O
• Molecular Weight: 132.058
• Hs Code.: 29051990
• European Community (EC) Number: 200-955-5
• NSC Number: 113
• UNII: RNO513716P
• DSSTox Substance ID: DTXSID8058796
• Nikkaji Number: J53.886H
• Wikidata: Q23978438
• Mol file: 76-37-9.mol

Synonyms:2,2,3,3-tetrafluoro-1-propanol

Chemical Property of 2,2,3,3-Tetrafluoro-1-propanol

Chemical Property:

• Appearance/Colour: colourless liquid
• Vapor Pressure: 13.1mmHg at 25°C
• Melting Point: -15 °C
• Refractive Index: n20/D 1.321(lit.)
• Boiling Point: 109.5 °C at 760 mmHg
• PKA: 13.05±0.10(Predicted)
• Flash Point: 31 °C
• PSA: 20.23000
• Density: 1.35 g/cm³
• LogP: 0.87910
• Storage Temp.: Flammables area
• Water Solubility.: Soluble in water.
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 132.01982740
• Heavy Atom Count: 8
• Complexity: 71.7

Purity/Quality:

99% ^*data from raw suppliers

2,2,3,3-Tetrafluoro-1-propanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, F, Xi
• Hazard Codes: Xn,F,Xi
• Statements: 10-20-36-36/37/38
• Safety Statements: 26-37/39-16-36/37-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(C(F)F)(F)F)O
• Uses: 2,2,3,3-Tetrafluoro-1-propanol, is used as an essential fluorinated fine chemical, the main application of TFP is as a dye solvent in CD-R(W) and DVD-R(W) industry. It is also used in making textile treatment agent and pharmaceuticals. This chemical is an ideal replacement for Freon 22 detergent.

Technology Process of 2,2,3,3-Tetrafluoro-1-propanol

There total 28 articles about 2,2,3,3-Tetrafluoro-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.4%

phosphonic acid bis-(2,2,3,3-tetrafluoro-propyl) ester (65611-25-8) + triethylamine (121-44-8) → 2,2,3,3-tetrafluoropropanol (76-37-9) + triethylammonium hydrogen 1H,1H,3H-tetrafluoropropyl phosphite

Guidance literature:

With water; for 1h; Ambient temperature;

Reference yield: 95.0%

3,5-Bis-(1,1,2,2-tetrafluoro-ethyl)-2,2,2-tris-(2,2,3,3-tetrafluoro-propoxy)-2λ5-[1,4,2]dioxaphospholane → 2,2,3,3-tetrafluoropropanol (76-37-9) + 2,2,3,3-tetrafluoropropionaldehyde (756-04-7) + (2,2,3,3-Tetrafluoro-1-hydroxy-propyl)-phosphonic acid bis-(2,2,3,3-tetrafluoro-propyl) ester

Guidance literature:

With water; In acetone; at 20 ℃; for 20h;

Reference yield: 95.0%

chloral hydrate (302-17-0) + di(1,1,3-trihydrotetrafluoropropyl)phenyl phosphonite (87651-42-1) → 2,2,3,3-tetrafluoropropanol (76-37-9) + (1,1,3-trihydrotetrafluoropropyl) (1-hydroxy-2,2,2-trichloroethyl)phenylphosphinate (1235818-80-0)

Guidance literature:

In benzene; at 30 - 40 ℃; for 12h; Inert atmosphere;

DOI:10.1134/S1070363210030096

upstream raw materials:

methanol

polytetrafluoroethylene

chloral hydrate

bis(1,1,3-trihydroperfluoropropyl) hydrogen phosphate

Downstream raw materials:

2,2,3,3-tetrafluoropropionaldehyde

(1,1,3-Trihydro-perfluor-propyl)-orthocarbonat

1,1,2,2-tetrafluoro-3-trifluoromethoxypropane

1,1,1,2,3,3-hexafluoro-3-(2,2,3,3-tetrafluoropropoxy)propane