2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)benzaldehyde

Base Information

Chemical Name:2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)benzaldehyde
CAS No.:1344997-54-1
Molecular Formula:C₂₁H₁₉F₃N₂O₂S
Molecular Weight:420.455
Hs Code.:

Synonyms:2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)benzaldehyde

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Chemical Property of 2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)benzaldehyde

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Technology Process of 2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)benzaldehyde

There total 9 articles about 2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1260023-43-5
2-ethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde

: 1344997-53-0
3-bromo-5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazole

: 1344997-54-1
2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)benzaldehyde

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 120 ℃; for 0.25h; Microwave irradiation;
DOI:10.1021/jm2016107

Reference yield:

: 1334607-79-2
4,4,5,5-tetramethyl-2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3,2-dioxaborolane

: 1344997-54-1
2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 1 h / 80 °C / Inert atmosphere; Microwave irradiation; Sealed vessel

2: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.75 h / 120 °C / Inert atmosphere; Microwave irradiation; Sealed vessel

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; N,N-dimethyl-formamide; 1: Suzuki Coupling / 2: Suzuki Coupling;

Reference yield:

: 108-36-1
1,3-dibromobenzene

: 1344997-54-1
2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)benzaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -70 - -65 °C

2.1: n-butyllithium; isopropylmagnesium bromide / hexane; tetrahydrofuran / 1.17 h / 0 °C

2.2: 2 h / -10 - 20 °C

2.3: 0.17 h / 0 °C

3.1: hydrogenchloride / water; tetrahydrofuran / 1 h / 20 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 80 °C

5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.75 h / 120 °C / Inert atmosphere; Microwave irradiation; Sealed vessel

With hydrogenchloride; potassium phosphate; n-butyllithium; isopropylmagnesium bromide; potassium acetate; diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; 5.1: Suzuki Coupling;