1-(4-fluorobenzyl)-N-(1-phenethylpiperidin-4-yl)-1H-benzo[d]imidazol-2-amine

Base Information

Chemical Name:1-(4-fluorobenzyl)-N-(1-phenethylpiperidin-4-yl)-1H-benzo[d]imidazol-2-amine
CAS No.:98088-84-7
Molecular Formula:C₂₇H₂₉FN₄
Molecular Weight:428.552
Hs Code.:

Synonyms:1-(4-fluorobenzyl)-N-(1-phenethylpiperidin-4-yl)-1H-benzo[d]imidazol-2-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-fluorobenzyl)-N-(1-phenethylpiperidin-4-yl)-1H-benzo[d]imidazol-2-amine

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Technology Process of 1-(4-fluorobenzyl)-N-(1-phenethylpiperidin-4-yl)-1H-benzo[d]imidazol-2-amine

There total 24 articles about 1-(4-fluorobenzyl)-N-(1-phenethylpiperidin-4-yl)-1H-benzo[d]imidazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 75970-99-9
norastemizole

: 103-63-9
1-phenyl-2-bromoethane

: 98088-84-7
1-(4-fluorobenzyl)-N-(1-phenethylpiperidin-4-yl)-1H-benzo[d]imidazol-2-amine

Guidance literature:: With potassium carbonate; In acetonitrile; at 85 ℃; for 12h;
DOI:10.1021/acsinfecdis.8b00272

Reference yield: 35.3%

: 4455-09-8
2-phenylethyl tosylate

: 75970-99-9
norastemizole

: 98088-84-7
1-(4-fluorobenzyl)-N-(1-phenethylpiperidin-4-yl)-1H-benzo[d]imidazol-2-amine

Guidance literature:: With sodium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 1h;
DOI:10.1021/acs.jmedchem.0c02261

Reference yield: 30.0%

: 122-78-1
phenylacetaldehyde

: 75970-64-8
1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-amine dihydrobromide

: 98088-84-7
1-(4-fluorobenzyl)-N-(1-phenethylpiperidin-4-yl)-1H-benzo[d]imidazol-2-amine

Guidance literature:: phenylacetaldehyde; 1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-amine dihydrobromide; With acetic acid; N-ethyl-N,N-diisopropylamine; In ethanol; at 40 ℃; for 1h;

With sodium cyanoborohydride; In ethanol; at 40 ℃; for 18h;
DOI:10.1016/j.bmc.2017.10.004