{3-[(2R,3R)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-oxiranyl}-(2,4,6-tris-methoxymethoxy-phenyl)-methanone

Base Information

Chemical Name:{3-[(2R,3R)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-oxiranyl}-(2,4,6-tris-methoxymethoxy-phenyl)-methanone
CAS No.:98314-88-6
Molecular Formula:C₃₃H₃₈O₁₄
Molecular Weight:658.656
Hs Code.:

{3-[(2R,3R)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-oxiranyl}-(2,4,6-tris-methoxymethoxy-phenyl)-methanone

Synonyms:{3-[(2R,3R)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-oxiranyl}-(2,4,6-tris-methoxymethoxy-phenyl)-methanone

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Chemical Property of {3-[(2R,3R)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-oxiranyl}-(2,4,6-tris-methoxymethoxy-phenyl)-methanone

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Technology Process of {3-[(2R,3R)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-oxiranyl}-(2,4,6-tris-methoxymethoxy-phenyl)-methanone

There total 9 articles about {3-[(2R,3R)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-oxiranyl}-(2,4,6-tris-methoxymethoxy-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 98314-87-5
(E)-3-[(2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-1-(2,4,6-tris-methoxymethoxy-phenyl)-propenone

: 98314-88-6
{3-[(2R,3R)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-oxiranyl}-(2,4,6-tris-methoxymethoxy-phenyl)-methanone

Guidance literature:: With sodium hydroxide; dihydrogen peroxide; In methanol; water; for 4h; Ambient temperature;
DOI:10.1248/cpb.33.1419

Reference yield:

: 65298-98-8
4-hydroxy-3-(methoxymethoxy)benzaldehyde

: 98314-88-6
{3-[(2R,3R)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-oxiranyl}-(2,4,6-tris-methoxymethoxy-phenyl)-methanone

Guidance literature:: Multi-step reaction with 8 steps

1: 66 percent / tert-BuOK / dimethylformamide / 3 h / Ambient temperature

2: 94 percent / NH₄Cl / methanol / 1 h / Heating

3: 97 percent / NaBH₄ / ethanol / 8 h / Ambient temperature

4: 70 percent / sulfuric acid (5percent) / acetic acid / 0.5 h / 70 °C

5: 63 percent / H₂ / Pd-C (5percent) / ethyl acetate; ethanol / Ambient temperature

6: 79 percent / NaH / tetrahydrofuran; paraffin / 2 h / Ambient temperature

7: 94 percent / NaOH / ethanol / 8 h

8: 97 percent / H₂O₂ (30percent), NaOH (5percent) / H₂O; methanol / 4 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; sulfuric acid; potassium tert-butylate; hydrogen; dihydrogen peroxide; sodium hydride; ammonium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; paraffin;
DOI:10.1248/cpb.33.1419

Reference yield:

: 7572-90-9
ethyl 2-bromo-3-(4-benzyloxy-3-methoxyphenyl)-3-oxopropionate

: 98314-88-6
{3-[(2R,3R)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-oxiranyl}-(2,4,6-tris-methoxymethoxy-phenyl)-methanone

Guidance literature:: Multi-step reaction with 8 steps

1: 66 percent / tert-BuOK / dimethylformamide / 3 h / Ambient temperature

2: 94 percent / NH₄Cl / methanol / 1 h / Heating

3: 97 percent / NaBH₄ / ethanol / 8 h / Ambient temperature

4: 70 percent / sulfuric acid (5percent) / acetic acid / 0.5 h / 70 °C

5: 63 percent / H₂ / Pd-C (5percent) / ethyl acetate; ethanol / Ambient temperature

6: 79 percent / NaH / tetrahydrofuran; paraffin / 2 h / Ambient temperature

7: 94 percent / NaOH / ethanol / 8 h

8: 97 percent / H₂O₂ (30percent), NaOH (5percent) / H₂O; methanol / 4 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; sulfuric acid; potassium tert-butylate; hydrogen; dihydrogen peroxide; sodium hydride; ammonium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; paraffin;
DOI:10.1248/cpb.33.1419