Technology Process of {3-[(2R,3R)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-oxiranyl}-(2,4,6-tris-methoxymethoxy-phenyl)-methanone
There total 9 articles about {3-[(2R,3R)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-oxiranyl}-(2,4,6-tris-methoxymethoxy-phenyl)-methanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide; dihydrogen peroxide;
In
methanol; water;
for 4h;
Ambient temperature;
DOI:10.1248/cpb.33.1419
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 66 percent / tert-BuOK / dimethylformamide / 3 h / Ambient temperature
2: 94 percent / NH4Cl / methanol / 1 h / Heating
3: 97 percent / NaBH4 / ethanol / 8 h / Ambient temperature
4: 70 percent / sulfuric acid (5percent) / acetic acid / 0.5 h / 70 °C
5: 63 percent / H2 / Pd-C (5percent) / ethyl acetate; ethanol / Ambient temperature
6: 79 percent / NaH / tetrahydrofuran; paraffin / 2 h / Ambient temperature
7: 94 percent / NaOH / ethanol / 8 h
8: 97 percent / H2O2 (30percent), NaOH (5percent) / H2O; methanol / 4 h / Ambient temperature
With
sodium hydroxide; sodium tetrahydroborate; sulfuric acid; potassium tert-butylate; hydrogen; dihydrogen peroxide; sodium hydride; ammonium chloride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; paraffin;
DOI:10.1248/cpb.33.1419
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 66 percent / tert-BuOK / dimethylformamide / 3 h / Ambient temperature
2: 94 percent / NH4Cl / methanol / 1 h / Heating
3: 97 percent / NaBH4 / ethanol / 8 h / Ambient temperature
4: 70 percent / sulfuric acid (5percent) / acetic acid / 0.5 h / 70 °C
5: 63 percent / H2 / Pd-C (5percent) / ethyl acetate; ethanol / Ambient temperature
6: 79 percent / NaH / tetrahydrofuran; paraffin / 2 h / Ambient temperature
7: 94 percent / NaOH / ethanol / 8 h
8: 97 percent / H2O2 (30percent), NaOH (5percent) / H2O; methanol / 4 h / Ambient temperature
With
sodium hydroxide; sodium tetrahydroborate; sulfuric acid; potassium tert-butylate; hydrogen; dihydrogen peroxide; sodium hydride; ammonium chloride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; paraffin;
DOI:10.1248/cpb.33.1419