3-phenyl-2,2-dideutero-3-((R)-1-phenylethylamino)propanenitrile

Base Information

• Chemical Name: 3-phenyl-2,2-dideutero-3-((R)-1-phenylethylamino)propanenitrile
• CAS No.: 1361110-53-3
• Molecular Formula: C₁₇H₁₈N₂
• Molecular Weight: 252.327
• Mol file: 1361110-53-3.mol

Synonyms:3-phenyl-2,2-dideutero-3-((R)-1-phenylethylamino)propanenitrile

Chemical Property of 3-phenyl-2,2-dideutero-3-((R)-1-phenylethylamino)propanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-phenyl-2,2-dideutero-3-((R)-1-phenylethylamino)propanenitrile

There total 2 articles about 3-phenyl-2,2-dideutero-3-((R)-1-phenylethylamino)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzaldehyde (100-52-7) → 3-phenyl-2,2-dideutero-3-((R)-1-phenylethylamino)propanenitrile (1361110-53-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 20 °C

2: lithium diisopropyl amide / -78 °C

With potassium carbonate; lithium diisopropyl amide; In methanol;

DOI:10.1016/j.tetlet.2012.01.004

Reference yield:

[D3]acetonitrile (2206-26-0) + (R)-benzylidene-(1-phenylethyl)amine (3129-98-4,56941-77-6,62696-51-9,69350-13-6,89103-76-4,98393-39-6,17480-71-6) → 3-phenyl-2,2-dideutero-3-((R)-1-phenylethylamino)propanenitrile (1361110-53-3)

Guidance literature:

With lithium diisopropyl amide; at -78 ℃; optical yield given as %de; diastereoselective reaction;

DOI:10.1016/j.tetlet.2012.01.004

Reference yield:

methanol (67-56-1) + 3-phenyl-2,2-dideutero-3-((R)-1-phenylethylamino)propanenitrile (1361110-53-3) → C18H19(2)H2NO2 (1361110-45-3)

Guidance literature:

methanol; 3-phenyl-2,2-dideutero-3-((R)-1-phenylethylamino)propanenitrile; With sulfuric acid; at 0 ℃; Reflux;

With water; sodium hydrogencarbonate; In methanol;

DOI:10.1016/j.tetlet.2012.01.004

upstream raw materials:

[D₃]acetonitrile

(R)-benzylidene-(1-phenylethyl)amine

benzaldehyde

Downstream raw materials:

C₁₈H₁₉⁽²⁾H₂NO₂