2-[7-methoxy-1'-neopentyl-4-(trifluoromethyl)-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]aniline

Base Information

• Chemical Name: 2-[7-methoxy-1'-neopentyl-4-(trifluoromethyl)-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]aniline
• CAS No.: 1554015-60-9
• Molecular Formula: C₂₅H₃₂F₃N₃O
• Molecular Weight: 447.544

Synonyms:2-[7-methoxy-1'-neopentyl-4-(trifluoromethyl)-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]aniline

Chemical Property of 2-[7-methoxy-1'-neopentyl-4-(trifluoromethyl)-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]aniline

Chemical Property:

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Technology Process of 2-[7-methoxy-1'-neopentyl-4-(trifluoromethyl)-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]aniline

There total 1 articles about 2-[7-methoxy-1'-neopentyl-4-(trifluoromethyl)-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-[7-methoxy-1'-neopentyl-4-(trifluoromethyl)-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]aniline (1554015-60-9)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In dichloromethane; at 20 - 40 ℃; for 5h; Inert atmosphere;

Reference yield: 96.0%

2-[7-methoxy-1'-neopentyl-4-(trifluoromethyl)-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]aniline (1554015-60-9) + 1,1'-Thiocarbonyldi-2(1H)-pyridone (102368-13-8) → 1-(2-isothiocyanatophenyl)-7-methoxy-1'-neopentyl-4-(trifluoromethyl)spiro[indoline-3,4'-piperidine] (1554015-71-2)

Guidance literature:

In dichloromethane; at 23 ℃; for 5h;

Reference yield:

2-[7-methoxy-1'-neopentyl-4-(trifluoromethyl)-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]aniline (1554015-60-9) + 4-Nitrophenyl chloroformate (7693-46-1) → 4-nitrophenyl 2-(7-methoxy-1'-neopentyl-4-(trifluoromethyl)spiro[indoline-3,4'-piperidine]-1-yl)phenylcarbamate (1557209-59-2)

Guidance literature:

With sodium carbonate; In dichloromethane; at 20 ℃; for 1h;

Downstream raw materials:

C₃₀H₃₄ClN₇OS

1'-neopentyl-1-(2-(5-phenyl-1,3,4-thiadiazol-2-ylamino)phenyl)-4-(trifluoromethyl)spiro[indoline-3,4'-piperidin]-7-ol

N-(2-(7-methoxy-1'-neopentyl-4-(trifluoromethyl)spiro[indoline-3,4'-piperidine]-1-yl)phenyl)-5-phenyl-1,3,4-thiadiazol-2-amine

N-(2-(4-chloro-7-methoxy-1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)hydrazinecarbothioamide

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