9-chloro-3-methyl-7-(2-chlorophenyl)-5H-pyrimido<4,5-d><2>-benzazepin-1(2H)-one

Base Information

Chemical Name:9-chloro-3-methyl-7-(2-chlorophenyl)-5H-pyrimido<4,5-d><2>-benzazepin-1(2H)-one
CAS No.:89376-28-3
Molecular Formula:C₁₉H₁₃Cl₂N₃O
Molecular Weight:370.238
Hs Code.:

Synonyms:9-chloro-3-methyl-7-(2-chlorophenyl)-5H-pyrimido<4,5-d><2>-benzazepin-1(2H)-one

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Chemical Property of 9-chloro-3-methyl-7-(2-chlorophenyl)-5H-pyrimido<4,5-d><2>-benzazepin-1(2H)-one

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Technology Process of 9-chloro-3-methyl-7-(2-chlorophenyl)-5H-pyrimido<4,5-d><2>-benzazepin-1(2H)-one

There total 4 articles about 9-chloro-3-methyl-7-(2-chlorophenyl)-5H-pyrimido<4,5-d><2>-benzazepin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 8-chloro-1-(2-chlorophenyl)-5H-2-benzazepine-5-carboxylic acid butyl ester

: 8-chloro-1-(2-chlorophenyl)-3H-2-benzazepine-5-carboxylic acid butyl ester

: 124-42-5
acetamidine hydrochloride

: 89376-28-3
9-chloro-3-methyl-7-(2-chlorophenyl)-5H-pyrimido<4,5-d><2>-benzazepin-1(2H)-one

Guidance literature:: With manganese dioxide; sodium methylate; In tetrahydrofuran; methanol; ethanol;

Reference yield:

: 101713-22-8
8-chloro-1-(2-chlorophenyl)-4,5-dibromo-4,5-dihydro-3H-2-benzazepine

: 89376-28-3
9-chloro-3-methyl-7-(2-chlorophenyl)-5H-pyrimido<4,5-d><2>-benzazepin-1(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 22 percent / 40percent aq. NaOH / dioxane / 1.5 h / Ambient temperature

With sodium hydroxide; In 1,4-dioxane;
DOI:10.1021/jo00362a007

Reference yield:

: 101713-12-6
8-chloro-1-(2-chlorophenyl)-3H-2-benzazepine hydrobromide

: 89376-28-3
9-chloro-3-methyl-7-(2-chlorophenyl)-5H-pyrimido<4,5-d><2>-benzazepin-1(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / Br₂ / CH₂Cl₂ / 19 h / Ambient temperature

2: 22 percent / 40percent aq. NaOH / dioxane / 1.5 h / Ambient temperature

With sodium hydroxide; bromine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jo00362a007