3-tert-butyl-isoxazole-5-carboxylic acid [3-nitro-4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amide

Base Information

Chemical Name:3-tert-butyl-isoxazole-5-carboxylic acid [3-nitro-4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amide
CAS No.:1332875-27-0
Molecular Formula:C₂₁H₁₆F₆N₄O₄
Molecular Weight:502.373
Hs Code.:

Synonyms:3-tert-butyl-isoxazole-5-carboxylic acid [3-nitro-4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amide

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Chemical Property of 3-tert-butyl-isoxazole-5-carboxylic acid [3-nitro-4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amide

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Technology Process of 3-tert-butyl-isoxazole-5-carboxylic acid [3-nitro-4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amide

There total 7 articles about 3-tert-butyl-isoxazole-5-carboxylic acid [3-nitro-4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1196104-05-8
3-tert-butyl-isoxazole-5-carbonyl chloride

: C₁₃H₆F₆N₃O₂^(1-)*Na⁽¹⁺⁾

: 1332875-27-0
3-tert-butyl-isoxazole-5-carboxylic acid [3-nitro-4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amide

Guidance literature:: In tetrahydrofuran; mineral oil; at 20 ℃; for 1h;

Reference yield:

: 39890-98-7
2,6-dichloro-4-(trifluoromethyl)pyridine

: 1332875-27-0
3-tert-butyl-isoxazole-5-carboxylic acid [3-nitro-4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 26 h / 110 °C

2.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 4 h / 80 °C / Inert atmosphere

3.1: hydrogen / 5%-palladium/activated carbon / methanol / 4 h / 20 °C / Inert atmosphere

4.1: sulfuric acid / 0 - 5 °C

4.2: 0 - 10 °C

4.3: pH 10 / Cooling

5.1: tetrahydrofuran; mineral oil / 1 h / 20 °C

6.1: tetrahydrofuran; mineral oil / 1 h / 20 °C

With pyridine; sulfuric acid; hydrogen; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; mineral oil; 2.1: Suzuki Coupling;

Reference yield:

: 1332875-24-7
(4-Methoxy-benzyl)-[4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amine

: 1332875-27-0
3-tert-butyl-isoxazole-5-carboxylic acid [3-nitro-4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / 5%-palladium/activated carbon / methanol / 4 h / 20 °C / Inert atmosphere

2.1: sulfuric acid / 0 - 5 °C

2.2: 0 - 10 °C

2.3: pH 10 / Cooling

3.1: tetrahydrofuran; mineral oil / 1 h / 20 °C

4.1: tetrahydrofuran; mineral oil / 1 h / 20 °C

With sulfuric acid; hydrogen; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; mineral oil;