(4-Methoxy-benzyl)-[4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amine

Base Information

• Chemical Name: (4-Methoxy-benzyl)-[4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amine
• CAS No.: 1332875-24-7
• Molecular Formula: C₂₁H₁₆F₆N₂O
• Molecular Weight: 426.361
• Mol file: 1332875-24-7.mol

Synonyms:(4-Methoxy-benzyl)-[4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amine

Chemical Property of (4-Methoxy-benzyl)-[4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-Methoxy-benzyl)-[4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amine

There total 3 articles about (4-Methoxy-benzyl)-[4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-chloro-N-(4-methoxybenzyl)-4-(trifluoromethyl)pyridin-2-amine (1332875-23-6) + 2-(trifluoromethyl)phenylboronic acid (1423-27-4) → (4-Methoxy-benzyl)-[4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amine (1332875-24-7)

Guidance literature:

With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; at 80 ℃; for 4h; Inert atmosphere;

Reference yield:

4-methoxy-benzylamine (2393-23-9) → (4-Methoxy-benzyl)-[4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amine (1332875-24-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 26 h / 110 °C

2: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 4 h / 80 °C / Inert atmosphere

With pyridine; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; 2: Suzuki Coupling;

Reference yield:

2,6-dichloro-4-(trifluoromethyl)pyridine (39890-98-7) → (4-Methoxy-benzyl)-[4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amine (1332875-24-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 26 h / 110 °C

2: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 4 h / 80 °C / Inert atmosphere

With pyridine; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; 2: Suzuki Coupling;

upstream raw materials:

6-chloro-N-(4-methoxybenzyl)-4-(trifluoromethyl)pyridin-2-amine

2-(trifluoromethyl)phenylboronic acid

4-methoxy-benzylamine

2,6-dichloro-4-(trifluoromethyl)pyridine

Downstream raw materials:

3-tert-butyl-isoxazole-5-carboxylic acid [3-nitro-4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amide

3-nitro-4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine

4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine

2-(3-tert-butyl-isoxazol-5-yl)-7-trifluoromethyl-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine