2-(6-(4-(2-(tert-butyldimethylsilyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate

Base Information

Chemical Name:2-(6-(4-(2-(tert-butyldimethylsilyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate
CAS No.:1181691-14-4
Molecular Formula:C₂₇H₃₇NO₄Si
Molecular Weight:467.681
Hs Code.:

Synonyms:2-(6-(4-(2-(tert-butyldimethylsilyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate

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Chemical Property of 2-(6-(4-(2-(tert-butyldimethylsilyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate

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Technology Process of 2-(6-(4-(2-(tert-butyldimethylsilyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate

There total 5 articles about 2-(6-(4-(2-(tert-butyldimethylsilyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1181691-13-3
6-(4-(2-(tert-butyldimethylsilyloxy)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

: 13831-31-7
Acetoxyacetyl chloride

: 1181691-14-4
2-(6-(4-(2-(tert-butyldimethylsilyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 215798-19-9
6-bromo-1,2,3,4-tetrahydroisoquinolinehydrochloride

: 1181691-14-4
2-(6-(4-(2-(tert-butyldimethylsilyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: (R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride / dichloromethane / 0.5 h / 20 °C

2: sodium hydrogencarbonate / ethanol; benzene / 3 h / 100 °C / Inert atmosphere; Microwave irradiation

3: methanol; sodium hydroxide / 0.33 h

4: triethylamine / dichloromethane / 20 °C

5: triethylamine / dichloromethane / 0.5 h / 20 °C

With methanol; (R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride; sodium hydrogencarbonate; triethylamine; sodium hydroxide; In ethanol; dichloromethane; benzene; 2: Suzuki Coupling;

Reference yield:

: 1181691-10-0
2-(6-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate

: 1181691-14-4
2-(6-(4-(2-(tert-butyldimethylsilyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / ethanol; benzene / 3 h / 100 °C / Inert atmosphere; Microwave irradiation

2: methanol; sodium hydroxide / 0.33 h

3: triethylamine / dichloromethane / 20 °C

4: triethylamine / dichloromethane / 0.5 h / 20 °C

With methanol; sodium hydrogencarbonate; triethylamine; sodium hydroxide; In ethanol; dichloromethane; benzene; 1: Suzuki Coupling;