Morpholineborane

Base Information

• Chemical Name: Morpholineborane
• CAS No.: 4856-95-5
• Molecular Formula: C4H12BNO
• Molecular Weight: 100.956
• Hs Code.: 29349990
• European Community (EC) Number: 225-450-7
• Mol file: 4856-95-5.mol

Synonyms:Morpholineborane;4856-95-5;Morpholine borane;NSC 93813;Boron, trihydro(morpholine-.kappa.N4)-, (T-4)-;DTXSID0052124;C4H12BNO;Borane-morpholine;Borane, compound with morpholine;Morpholine--borane;Trihydro(morpholine-N4)boron;SCHEMBL435893;DTXCID2030693;C4-H12-B-N-O;YJROYUJAFGZMJA-UHFFFAOYSA-N;AMY14878;EINECS 225-450-7;Tox21_303932;MFCD00066736;AKOS025311064;NCGC00357171-01;BS-42302;CAS-4856-95-5;AI3-52117;Boron, trihydro(morpholine-N4)-, (T-4)-;FT-0623162;M0898;F14226;Boron, trihydro(morpholine-kappaN4)-, (T-4)-

Chemical Property of Morpholineborane

Chemical Property:

• Appearance/Colour: colorless to white crystalline powder
• Vapor Pressure: 10.4mmHg at 25°C
• Melting Point: 97-99 °C(lit.)
• Boiling Point: 128.9 °C at 760 mmHg
• Flash Point: 35.6 °C
• PSA: 21.26000
• LogP: -1.24890
• Storage Temp.: Refrigerator
• Water Solubility.: MAY DECOMPOSE
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 98.0777191
• Heavy Atom Count: 7
• Complexity: 34.5

Purity/Quality:

97% ^*data from raw suppliers

Morpholineborane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C, Xi
• Hazard Codes: C,Xi
• Statements: 34-36/37/38
• Safety Statements: 26-27-28-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [B].C1COCCN1
• Uses: Morpholineborane can be used as reducing agent for aldehydes and ketones. It is use-ful in acid media where sodium borohydride is inef-fectual because of its instability in acid.

Technology Process of Morpholineborane

There total 8 articles about Morpholineborane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

morpholine (110-91-8,99108-56-2) + sodium tetrahydroborate (16940-66-2) → morpholine - borane (1/1) (4856-95-5)

Guidance literature:

With ammonium sulfate; In tetrahydrofuran; for 6h; Reflux;

DOI:10.1021/acs.inorgchem.5b00572

Reference yield: 97.0%

morpholine (110-91-8,99108-56-2) + borane-ammonia complex (10043-11-5) → morpholine - borane (1/1) (4856-95-5)

Guidance literature:

In tetrahydrofuran; for 1h; Reflux;

DOI:10.1039/c4ra03397c

Reference yield: 86.0%

morpholine (110-91-8,99108-56-2) + sodium tetrahydroborate (16940-66-2) + trifluoroborane diethyl ether (109-63-7) → morpholine - borane (1/1) (4856-95-5)

Guidance literature:

In tetrahydrofuran; react. in THF, treatment of reat.-mixture with 10% aq. NaOH, separation of upper layer, removal of THF, cooling to 0°C;; drying in vac. at 60-70°C; purity: 99.8%;;

upstream raw materials:

morpholine

diborane

sodium tetrahydroborate

trifluoroborane diethyl ether

Downstream raw materials:

4-chloromorpholine

chloride

morpholinium

hydrogen