methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate

Base Information

Chemical Name:methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate
CAS No.:1268383-98-7
Molecular Formula:C₂₈H₂₁F₅N₆O₃
Molecular Weight:584.505
Hs Code.:

Synonyms:methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate

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Chemical Property of methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate

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Technology Process of methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate

There total 8 articles about methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1105058-57-8
2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine

: 1268385-58-5
methyl bromo{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate

: 1268383-98-7
methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 287714-35-6
2-chloro-pyrimidine-5-carboxylic acid methyl ester

: 1268383-98-7
methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate

Guidance literature:: Multi-step reaction with 7 steps

1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 120 °C / Inert atmosphere; Microwave

2: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

3: thionyl chloride / 2 h / Reflux

4: diethyl ether / 20 °C

5: triethylamine; silver benzoate / Reflux

6: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux

7: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

With potassium phosphate; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); water; silver benzoate; potassium carbonate; triethylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; diethyl ether; water; N,N-dimethyl-formamide;

Reference yield:

: 1186482-51-8
(4-propoxy-2-(trifluoromethyl)phenyl)boronic acid

: 1268383-98-7
methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate

Guidance literature:: Multi-step reaction with 7 steps

1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 120 °C / Inert atmosphere; Microwave

2: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

3: thionyl chloride / 2 h / Reflux

4: diethyl ether / 20 °C

5: triethylamine; silver benzoate / Reflux

6: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux

7: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

With potassium phosphate; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); water; silver benzoate; potassium carbonate; triethylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; diethyl ether; water; N,N-dimethyl-formamide;