methyl bromo{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate

Base Information

Chemical Name:methyl bromo{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate
CAS No.:1268385-58-5
Molecular Formula:C₁₇H₁₆BrF₃N₂O₃
Molecular Weight:433.225
Hs Code.:

Synonyms:methyl bromo{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate

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Chemical Property of methyl bromo{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate

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Technology Process of methyl bromo{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate

There total 7 articles about methyl bromo{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1268385-57-4
methyl {2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate

: 1268385-58-5
methyl bromo{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate

Guidance literature:: With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 3h; Reflux;

Reference yield:

: 287714-35-6
2-chloro-pyrimidine-5-carboxylic acid methyl ester

: 1268385-58-5
methyl bromo{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 120 °C / Inert atmosphere; Microwave

2: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

3: thionyl chloride / 2 h / Reflux

4: diethyl ether / 20 °C

5: triethylamine; silver benzoate / Reflux

6: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux

With potassium phosphate; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); water; silver benzoate; triethylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; diethyl ether; water;

Reference yield:

: 1186482-51-8
(4-propoxy-2-(trifluoromethyl)phenyl)boronic acid

: 1268385-58-5
methyl bromo{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 120 °C / Inert atmosphere; Microwave

2: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

3: thionyl chloride / 2 h / Reflux

4: diethyl ether / 20 °C

5: triethylamine; silver benzoate / Reflux

6: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux

With potassium phosphate; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); water; silver benzoate; triethylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; diethyl ether; water;