2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinecarboxylic acid

Base Information

• Chemical Name: 2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinecarboxylic acid
• CAS No.: 1268385-55-2
• Molecular Formula: C₁₅H₁₃F₃N₂O₃
• Molecular Weight: 326.275
• Mol file: 1268385-55-2.mol

Synonyms:2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinecarboxylic acid

Chemical Property of 2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinecarboxylic acid

There total 3 articles about 2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl 2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinecarboxylate (1204529-59-8) → 2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinecarboxylic acid (1268385-55-2)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

2-chloro-pyrimidine-5-carboxylic acid methyl ester (287714-35-6) → 2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinecarboxylic acid (1268385-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 120 °C / Inert atmosphere; Microwave

2: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

With potassium phosphate; water; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

(4-propoxy-2-(trifluoromethyl)phenyl)boronic acid (1186482-51-8) → 2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinecarboxylic acid (1268385-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 120 °C / Inert atmosphere; Microwave

2: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

With potassium phosphate; water; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water;

upstream raw materials:

2-chloro-pyrimidine-5-carboxylic acid methyl ester

(4-propoxy-2-(trifluoromethyl)phenyl)boronic acid

methyl 2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinecarboxylate

Downstream raw materials:

methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate

methyl {2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate

methyl bromo{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}acetate

C₁₅H₁₂ClF₃N₂O₂