(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-piperidin-3-yloxy)-phenyl]-amine hydrochloride

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Chemical Name:(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-piperidin-3-yloxy)-phenyl]-amine hydrochloride
CAS No.:1332720-87-2
Molecular Formula:C₁₈H₁₈ClFN₄OS*ClH
Molecular Weight:429.345
Hs Code.:

Synonyms:(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-piperidin-3-yloxy)-phenyl]-amine hydrochloride

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Chemical Property of (6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-piperidin-3-yloxy)-phenyl]-amine hydrochloride

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Technology Process of (6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-piperidin-3-yloxy)-phenyl]-amine hydrochloride

There total 7 articles about (6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-piperidin-3-yloxy)-phenyl]-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332712-32-9
(R)-3-(2-amino-5-fluoro-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester

: 56844-14-5
4,6-dichloro-5-methylthieno[2,3-d]pyrimidine

: 1332720-87-2
(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-piperidin-3-yloxy)-phenyl]-amine hydrochloride

Guidance literature:: (R)-3-(2-amino-5-fluoro-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester; 4,6-dichloro-5-methylthieno[2,3-d]pyrimidine; With toluene-4-sulfonic acid; In 1,4-dioxane; at 100 ℃; for 72h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With hydrogenchloride; In methanol;

Reference yield:

: 143900-43-0
tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate

: 1332720-87-2
(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-piperidin-3-yloxy)-phenyl]-amine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / 0 °C

1.2: 16 h

2.1: ammonium formate / palladium / methanol / 1.5 h / 20 °C

3.1: toluene-4-sulfonic acid / 1,4-dioxane / 72 h / 100 °C

3.2: 2 h / 20 °C

With ammonium formate; toluene-4-sulfonic acid; lithium hexamethyldisilazane; palladium; In tetrahydrofuran; 1,4-dioxane; methanol;

Reference yield:

: 446-35-5
2,4-Difluoronitrobenzene

: 1332720-87-2
(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-piperidin-3-yloxy)-phenyl]-amine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / 0 °C

1.2: 16 h

2.1: ammonium formate / palladium / methanol / 1.5 h / 20 °C

3.1: toluene-4-sulfonic acid / 1,4-dioxane / 72 h / 100 °C

3.2: 2 h / 20 °C

With ammonium formate; toluene-4-sulfonic acid; lithium hexamethyldisilazane; palladium; In tetrahydrofuran; 1,4-dioxane; methanol;