(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-1-methanesulfonylpiperidin-3-yloxy)-phenyl]-amine

Base Information

Chemical Name:(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-1-methanesulfonylpiperidin-3-yloxy)-phenyl]-amine
CAS No.:1332720-88-3
Molecular Formula:C₁₉H₂₀ClFN₄O₃S₂
Molecular Weight:470.976
Hs Code.:

Synonyms:(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-1-methanesulfonylpiperidin-3-yloxy)-phenyl]-amine

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Chemical Property of (6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-1-methanesulfonylpiperidin-3-yloxy)-phenyl]-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-1-methanesulfonylpiperidin-3-yloxy)-phenyl]-amine

There total 8 articles about (6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-1-methanesulfonylpiperidin-3-yloxy)-phenyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332720-87-2
(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-piperidin-3-yloxy)-phenyl]-amine hydrochloride

: 124-63-0
methanesulfonyl chloride

: 1332720-88-3
(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-1-methanesulfonylpiperidin-3-yloxy)-phenyl]-amine

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 143900-43-0
tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate

: 1332720-88-3
(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-1-methanesulfonylpiperidin-3-yloxy)-phenyl]-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / 0 °C

1.2: 16 h

2.1: ammonium formate / palladium / methanol / 1.5 h / 20 °C

3.1: toluene-4-sulfonic acid / 1,4-dioxane / 72 h / 100 °C

3.2: 2 h / 20 °C

4.1: triethylamine / dichloromethane / 4 h / 20 °C

With ammonium formate; toluene-4-sulfonic acid; triethylamine; lithium hexamethyldisilazane; palladium; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 446-35-5
2,4-Difluoronitrobenzene

: 1332720-88-3
(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-1-methanesulfonylpiperidin-3-yloxy)-phenyl]-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / 0 °C

1.2: 16 h

2.1: ammonium formate / palladium / methanol / 1.5 h / 20 °C

3.1: toluene-4-sulfonic acid / 1,4-dioxane / 72 h / 100 °C

3.2: 2 h / 20 °C

4.1: triethylamine / dichloromethane / 4 h / 20 °C

With ammonium formate; toluene-4-sulfonic acid; triethylamine; lithium hexamethyldisilazane; palladium; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;