4,6-Dichloro-5-methylthieno[2,3-d]pyrimidine

Base Information

• Chemical Name: 4,6-Dichloro-5-methylthieno[2,3-d]pyrimidine
• CAS No.: 56844-14-5
• Molecular Formula: C7H4Cl2N2S
• Molecular Weight: 219.094
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID601258983
• Mol file: 56844-14-5.mol

Synonyms:4,6-Dichloro-5-methylthieno[2,3-d]pyrimidine;56844-14-5;4,6-dichloro-5-methyl-Thieno[2,3-d]pyrimidine;SCHEMBL1604973;LDYLXPXJZAKXCN-UHFFFAOYSA-N;DTXSID601258983;FT-0702368

Chemical Property of 4,6-Dichloro-5-methylthieno[2,3-d]pyrimidine

Chemical Property:

• PSA: 54.02000
• LogP: 3.30650
• Storage Temp.: 2-8°C
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 217.9472247
• Heavy Atom Count: 12
• Complexity: 181

Purity/Quality:

99% ^*data from raw suppliers

4,6-Dichloro-5-methylthieno[2,3-d]pyrimidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(SC2=C1C(=NC=N2)Cl)Cl

Technology Process of 4,6-Dichloro-5-methylthieno[2,3-d]pyrimidine

There total 7 articles about 4,6-Dichloro-5-methylthieno[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

6-chloro-5-methylthieno[2,3-d]pyrimidin-4(3H)-one (56844-42-9) → 4,6-dichloro-5-methylthieno[2,3-d]pyrimidine (56844-14-5)

Guidance literature:

With trichlorophosphate; Reflux;

DOI:10.1016/j.ejmech.2016.07.035

Reference yield:

ethyl 2-aminothiophene-3-carboxylate (31891-06-2) → 4,6-dichloro-5-methylthieno[2,3-d]pyrimidine (56844-14-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 150 - 180 °C

2: N-chloro-succinimide; acetic acid / 1.5 h / 95 °C

3: thionyl chloride / N,N-dimethyl-formamide / 2 h / Reflux

With N-chloro-succinimide; thionyl chloride; acetic acid; In N,N-dimethyl-formamide;

Reference yield:

5-methylthieno[2,3-d]pyrimidin-4-ol (43088-64-8) → 4,6-dichloro-5-methylthieno[2,3-d]pyrimidine (56844-14-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N-chloro-succinimide; acetic acid / 1.5 h / 95 °C

2: thionyl chloride / N,N-dimethyl-formamide / 2 h / Reflux

With N-chloro-succinimide; thionyl chloride; acetic acid; In N,N-dimethyl-formamide;

upstream raw materials:

6-chloro-5-methylthieno[2,3-d]pyrimidin-4(3H)-one

ethyl 2-aminothiophene-3-carboxylate

5-methylthieno[2,3-d]pyrimidin-4-ol

2-amino-4-methyl-thiophene-3-carboxylic acid ethyl ester

Downstream raw materials:

2-(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluorophenol

N-{2-[2-(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluoro-phenoxy]-propyl}-acetamide

{2-[2-(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluoro-phenoxy]-propyl}-carbamic acid tert-butyl ester

(6-chloro-5-methyl-thieno[2,3-d]pyrimidin-4-yl)-[4-fluoro-2-((R)-piperidin-3-yloxy)-phenyl]-amine hydrochloride