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1977-06-6

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1977-06-6 Usage

General Description

4-METHYL-5-THIAZOLYL METHANOL is a chemical compound with the molecular formula C5H7NOS. It is a colorless to light yellow liquid, and it is commonly used as a flavoring agent in the food industry. It is also used in the synthesis of pharmaceuticals and pesticides. This chemical is known for its strong odor and is commonly used in the perfume industry as well. 4-METHYL-5-THIAZOLYL METHANOL has also been studied for its potential antimicrobial and antifungal properties, making it a versatile and useful chemical compound with a wide range of applications.

Check Digit Verification of cas no

The CAS Registry Mumber 1977-06-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,7 and 7 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1977-06:
(6*1)+(5*9)+(4*7)+(3*7)+(2*0)+(1*6)=106
106 % 10 = 6
So 1977-06-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H7NOS/c1-4-5(2-7)8-3-6-4/h3,7H,2H2,1H3

1977-06-6 Well-known Company Product Price

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  • (Code)Product description
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  • Alfa Aesar

  • (H61900)  4-Methyl-5-thiazolemethanol, 97%   

  • 1977-06-6

  • 250mg

  • 571.0CNY

  • Detail
  • Alfa Aesar

  • (H61900)  4-Methyl-5-thiazolemethanol, 97%   

  • 1977-06-6

  • 1g

  • 1712.0CNY

  • Detail

1977-06-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name (4-Methyl-1,3-thiazol-5-yl)methanol

1.2 Other means of identification

Product number -
Other names (4-Methylthiazol-5-yl)methanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1977-06-6 SDS

1977-06-6Relevant articles and documents

Design, synthesis and biological evaluation of novel thiazole-derivatives as mitochondrial targeting inhibitors of cancer cells

Dang, Xin,Lei, Shuwen,Luo, Shuhua,Hu, Yixin,Wang, Juntao,Zhang, Dongdong,Lu, Dan,Jiang, Faqin,Fu, Lei

, (2021/06/16)

Mitochondria are pivotal energy production sources for cells to maintain necessary metabolism activities. Targeting dysfunctional mitochondrial features has been a hotspot for mitochondrial-related disease researches. Investigation with cancerous mitochondrial metabolism is a continuing concern within tumor therapy. Herein, we set out to assess the anti-cancer activities of a novel family of TPP-thiazole derivatives based on our earlier research on mitochondrial targeting agents. Specifically, we designed and synthesized a series of TPP-thiazole derivatives and revealed by the MTT assay that most synthesized compounds effectively inhibited three cancer cell lines (HeLa, PC3 and MCF-7). After structure modifications, we explored the SAR relationships and identified the most promising compound R13 (IC50 of 5.52 μM) for further investigation. In the meantime, we performed ATP production assay to assess the selected compounds inhibitory effect on HeLa cells energy production. The results displayed the test compounds significantly restrained ATP production of cancer cells. Overall, we have designed and synthesized a series of compounds which exhibited significant cytotoxicity against cancer cells and effectively inhibited mitochondrial energy production.

Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity

Curreli, Francesca,Kwon, Young Do,Zhang, Hongtao,Scacalossi, Daniel,Belov, Dmitry S.,Tikhonov, Artur A.,Andreev, Ivan A.,Altieri, Andrea,Kurkin, Alexander V.,Kwong, Peter D.,Debnath, Asim K.

, p. 6909 - 6927 (2015/09/22)

Earlier we reported the discovery and design of NBD-556 and their analogs which demonstrated their potential as HIV-1 entry inhibitors. However, progress in developing these inhibitors has been stymied by their CD4-agonist properties, an unfavorable trait for use as drug. Here, we demonstrate the successful conversion of a full CD4-agonist (NBD-556) through a partial CD4-agonist (NBD-09027), to a full CD4-antagonist (NBD-11021) by structure-based modification of the critical oxalamide midregion, previously thought to be intolerant of modification. NBD-11021 showed unprecedented neutralization breath for this class of inhibitors, with pan-neutralization against a panel of 56 Env-pseudotyped HIV-1 representing diverse subtypes of clinical isolates (IC50 as low as 270 nM). The cocrystal structure of NBD-11021 complexed to a monomeric HIV-1 gp120 core revealed its detail binding characteristics. The study is expected to provide a framework for further development of NBD series as HIV-1 entry inhibitors for clinical application against AIDS.

METHYL SULFANYL PYRMIDMES USEFUL AS ANTIINFLAMMATORIES, ANALGESICS, AND ANTIEPILEPTICS

-

Page/Page column 149, (2010/12/18)

The present invention relates to pyrimidine derivatives of Formula (Ia) and (Ib) (including tautomers, isomers, prodrugs, and pharmaceutically acceptable salts thereof). Said compounds are useful in the treatment of pain (such as neuropathic pain), inflammation, and epilepsy (by acting as anticonvulsants). Methods of medical treatment making use of said compounds, as well as additional compounds of Formula (IIa) and (IIb), are also disclosed.

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