4-(2-(methylamino)ethoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole-2-oxide

Base Information

• Chemical Name: 4-(2-(methylamino)ethoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole-2-oxide
• CAS No.: 1245575-39-6
• Molecular Formula: C₁₁H₁₃N₃O₅S
• Molecular Weight: 299.307
• Mol file: 1245575-39-6.mol

Synonyms:4-(2-(methylamino)ethoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole-2-oxide

Chemical Property of 4-(2-(methylamino)ethoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole-2-oxide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(2-(methylamino)ethoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole-2-oxide

There total 1 articles about 4-(2-(methylamino)ethoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole-2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(2-hydroxyethyl)(methyl)amine (109-83-1) + 3,4-bis(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide (66074-00-8) → 4-(2-(methylamino)ethoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole-2-oxide (1245575-39-6)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃;

DOI:10.1021/jm1014814

Reference yield: 92.7%

succinic acid anhydride (108-30-5) + 4-(2-(methylamino)ethoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole-2-oxide (1245575-39-6) → 4-(2-(3-carboxy-N-methylpropanamido)ethoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole-2-oxide

Guidance literature:

With dmap; In dichloromethane; at 40 ℃; for 5h;

DOI:10.1039/c5md00158g

Reference yield:

(E)-4-(3-oxo-3-(((tetrahydro-2H-pyran-2-yl)-oxy)amino)prop-1-en-1-yl)benzoic acid (1143459-86-2) + 4-(2-(methylamino)ethoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole-2-oxide (1245575-39-6) → C26H28N4O9S

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

DOI:10.1248/cpb.c14-00449

upstream raw materials:

(2-hydroxyethyl)(methyl)amine

3,4-bis(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide