N₄-(3-aminophenyl)-5-fluoro-N₂-(4-((2-methoxyethoxy)methoxy)phenyl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₄-(3-aminophenyl)-5-fluoro-N₂-(4-((2-methoxyethoxy)methoxy)phenyl)pyrimidine-2,4-diamine
• CAS No.: 1616380-53-0
• Molecular Formula: C₂₀H₂₂FN₅O₃
• Molecular Weight: 399.425

Synonyms:N₄-(3-aminophenyl)-5-fluoro-N₂-(4-((2-methoxyethoxy)methoxy)phenyl)pyrimidine-2,4-diamine

Chemical Property of N₄-(3-aminophenyl)-5-fluoro-N₂-(4-((2-methoxyethoxy)methoxy)phenyl)pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of N₄-(3-aminophenyl)-5-fluoro-N₂-(4-((2-methoxyethoxy)methoxy)phenyl)pyrimidine-2,4-diamine

There total 7 articles about N₄-(3-aminophenyl)-5-fluoro-N₂-(4-((2-methoxyethoxy)methoxy)phenyl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-fluoro-N2-(4-((2-methoxyethoxy)methoxy)phenyl)-N4-(3-nitrophenyl)pyrimidine-2,4-diamine (1616380-52-9) → N4-(3-aminophenyl)-5-fluoro-N2-(4-((2-methoxyethoxy)methoxy)phenyl)pyrimidine-2,4-diamine (1616380-53-0)

Guidance literature:

With palladium on activated charcoal; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 18h; under 6000.6 Torr; Inert atmosphere; Autoclave;

Reference yield:

4-[(2-methoxyethoxy)methoxy]aniline → N4-(3-aminophenyl)-5-fluoro-N2-(4-((2-methoxyethoxy)methoxy)phenyl)pyrimidine-2,4-diamine (1616380-53-0)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / ethanol / 24 h / Reflux

2: palladium on activated charcoal; hydrogen / methanol / 20 °C / 3620.13 Torr / Inert atmosphere; Autoclave

With palladium on activated charcoal; hydrogen; acetic acid; In methanol; ethanol;

Reference yield:

2-chloro-N4-(3-nitrophenyl)-5-fluoro-4-pyrimidineamine (575474-26-9) → N4-(3-aminophenyl)-5-fluoro-N2-(4-((2-methoxyethoxy)methoxy)phenyl)pyrimidine-2,4-diamine (1616380-53-0)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / ethanol / 24 h / Reflux

2: palladium on activated charcoal; hydrogen / methanol / 20 °C / 3620.13 Torr / Inert atmosphere; Autoclave

With palladium on activated charcoal; hydrogen; acetic acid; In methanol; ethanol;

upstream raw materials:

5-fluoro-N₂-(4-((2-methoxyethoxy)methoxy)phenyl)-N₄-(3-nitrophenyl)pyrimidine-2,4-diamine

4-nitro-aniline

2-chloro-N₄-(3-nitrophenyl)-5-fluoro-4-pyrimidineamine

4-nitro-phenol

Downstream raw materials:

N-(3-((5-fluoro-2-((4-hydroxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide

N-(3-((5-fluoro-2-((4-hydroxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)-2,3-dihydroxypropanamide

N-(3-((5-fluoro-2-((4-((2-methoxyethoxy)methoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide

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