(2R)-2',4'-difluoro-2-(1'-methoxy-1'-methylethoxy)propiophenone

Base Information

• Chemical Name: (2R)-2',4'-difluoro-2-(1'-methoxy-1'-methylethoxy)propiophenone
• CAS No.: 853243-84-2
• Molecular Formula: C₁₃H₁₆F₂O₃
• Molecular Weight: 258.265
• Mol file: 853243-84-2.mol

Synonyms:(2R)-2',4'-difluoro-2-(1'-methoxy-1'-methylethoxy)propiophenone

Chemical Property of (2R)-2',4'-difluoro-2-(1'-methoxy-1'-methylethoxy)propiophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2',4'-difluoro-2-(1'-methoxy-1'-methylethoxy)propiophenone

There total 2 articles about (2R)-2',4'-difluoro-2-(1'-methoxy-1'-methylethoxy)propiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.7%

2-Methoxypropene (116-11-0) + (R)-1-(2,4-difluorophenyl)-2-hydroxypropan-1-one (126918-16-9) → (2R)-2',4'-difluoro-2-(1'-methoxy-1'-methylethoxy)propiophenone (853243-84-2)

Guidance literature:

2-Methoxypropene; (R)-1-(2,4-difluorophenyl)-2-hydroxypropan-1-one; With pyridinium p-toluenesulfonate; In tert-butyl methyl ether; at 0 - 10 ℃; for 1h;

2-Methoxypropene; With pyridinium p-toluenesulfonate; at 10 - 20 ℃; for 2h;

Reference yield: 60.0%

2-Methoxypropene (116-11-0) + (R)-1-(2,4-difluorophenyl)-2-hydroxypropan-1-one (126918-16-9) + 1-(2,4-difluorophenyl)-1-hydroxy-2-propanone (146071-45-6) → (2R)-2',4'-difluoro-2-(1'-methoxy-1'-methylethoxy)propiophenone (853243-84-2)

Guidance literature:

With pyridinium p-toluenesulfonate; In toluene; at 10 - 20 ℃; for 1.5h;

Reference yield:

(2R)-2',4'-difluoro-2-(1'-methoxy-1'-methylethoxy)propiophenone (853243-84-2) + trimethylsulphonium bromide (3084-53-5) → (2R,3R)-3-(2',4'-difluorophenyl)-3,4-epoxy-2-(1'-methoxy-1'-methylethoxy)butane (853243-86-4) + C14H18F2O3

Guidance literature:

trimethylsulphonium bromide; With sodium hydride; In dimethyl sulfoxide; at 16 - 25 ℃; for 2.5h;

(2R)-2',4'-difluoro-2-(1'-methoxy-1'-methylethoxy)propiophenone; In dimethyl sulfoxide; toluene; paraffin; at 20 ℃; for 3.25h; Product distribution / selectivity;

upstream raw materials:

2-Methoxypropene

(R)-1-(2,4-difluorophenyl)-2-hydroxypropan-1-one

1-(2,4-difluorophenyl)-1-hydroxy-2-propanone

Downstream raw materials:

(2R,3R)-3-(2',4'-difluorophenyl)-3,4-epoxy-2-(1'-methoxy-1'-methylethoxy)butane