dimethyl [(RS)-1-(benzyloxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate

Base Information

• Chemical Name: dimethyl [(RS)-1-(benzyloxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate
• CAS No.: 1367824-38-1
• Molecular Formula: C₁₉H₂₄NO₅PS
• Molecular Weight: 409.443
• Mol file: 1367824-38-1.mol

Synonyms:dimethyl [(RS)-1-(benzyloxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate

Chemical Property of dimethyl [(RS)-1-(benzyloxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of dimethyl [(RS)-1-(benzyloxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate

There total 4 articles about dimethyl [(RS)-1-(benzyloxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

sodium methylate (124-41-4) + diphenyl <1-<(benzyloxycarbonyl)amino>-3-(phenylthio)propyl>phosphonate (100432-03-9) → dimethyl [(RS)-1-(benzyloxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate (1367824-38-1)

Guidance literature:

With methanol; In 1,4-dioxane; at 20 ℃;

Reference yield: 31.0%

O-benzyl carbamate (621-84-1) + 3-phenylsulfanyl-propionaldehyde (27098-65-3) + Dimethyl phosphite (868-85-9) → dimethyl [(RS)-1-(benzyloxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate (1367824-38-1)

Guidance literature:

With acetyl chloride; at 0 - 20 ℃;

Reference yield:

thiophenol (108-98-5) → dimethyl [(RS)-1-(benzyloxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate (1367824-38-1)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: acetic acid / 1 h / 80 °C

3: methanol / 1,4-dioxane / 20 °C

With methanol; acetic acid; triethylamine; In 1,4-dioxane; dichloromethane;

upstream raw materials:

O-benzyl carbamate

3-phenylsulfanyl-propionaldehyde

Dimethyl phosphite

sodium methylate

Downstream raw materials:

[(RS)-1-amino-3-(phenylsulfanyl)propyl]phosphonic acid