diethyl 2-(4-fluorophenyl)-3-(4-methoxyphenyl)-1,2-dihydroisoquinolin-1-ylphosphonate

Base Information

Chemical Name:diethyl 2-(4-fluorophenyl)-3-(4-methoxyphenyl)-1,2-dihydroisoquinolin-1-ylphosphonate
CAS No.:1132675-35-4
Molecular Formula:C₂₆H₂₇FNO₄P
Molecular Weight:467.477
Hs Code.:

Synonyms:diethyl 2-(4-fluorophenyl)-3-(4-methoxyphenyl)-1,2-dihydroisoquinolin-1-ylphosphonate

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Chemical Property of diethyl 2-(4-fluorophenyl)-3-(4-methoxyphenyl)-1,2-dihydroisoquinolin-1-ylphosphonate

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Technology Process of diethyl 2-(4-fluorophenyl)-3-(4-methoxyphenyl)-1,2-dihydroisoquinolin-1-ylphosphonate

There total 2 articles about diethyl 2-(4-fluorophenyl)-3-(4-methoxyphenyl)-1,2-dihydroisoquinolin-1-ylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 257882-74-9
2-[2-oxo-2-(4'-methoxyphenyl)ethyl]benzaldehyde

: 762-04-9
phosphonic acid diethyl ester

: 371-40-4
4-fluoroaniline

: 1132675-35-4
diethyl 2-(4-fluorophenyl)-3-(4-methoxyphenyl)-1,2-dihydroisoquinolin-1-ylphosphonate

Guidance literature:: With copper(l) iodide; In 1,2-dichloro-ethane; at 70 ℃; for 18h; Inert atmosphere; Molecular sieve;
DOI:10.1016/j.tet.2008.12.038

Reference yield: 64.0%

: 762-04-9
phosphonic acid diethyl ester

: 6630-33-7
ortho-bromobenzaldehyde

: 371-40-4
4-fluoroaniline

: 768-60-5
4-methoxyphenylacetylen

: 1132675-35-4
diethyl 2-(4-fluorophenyl)-3-(4-methoxyphenyl)-1,2-dihydroisoquinolin-1-ylphosphonate

Guidance literature:: ortho-bromobenzaldehyde; 4-methoxyphenylacetylen; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 50 - 60 ℃;

phosphonic acid diethyl ester; 4-fluoroaniline; With copper(II) bis(trifluoromethanesulfonate); In tetrahydrofuran; at 50 - 60 ℃; Molecular sieve;
DOI:10.1016/j.tetlet.2009.05.106