6-TRIFLUOROMETHYLOXINDOLE

Base Information

• Chemical Name: 6-TRIFLUOROMETHYLOXINDOLE
• CAS No.: 1735-89-3
• Molecular Formula: C9H6F3NO
• Molecular Weight: 201.148
• Hs Code.: 29337900
• Mol file: 1735-89-3.mol

Synonyms:2-Indolinone,6-(trifluoromethyl)- (7CI,8CI);2-Oxo-6-(trifluoromethyl)indoline;6-(Trifluoromethyl)-2-oxindole;6-(Trifluoromethyl)-1,3-dihydro-2H-indol-2-one;

Chemical Property of 6-TRIFLUOROMETHYLOXINDOLE

Chemical Property:

• Vapor Pressure: 0.00215mmHg at 25°C
• Melting Point: 184-186 ºC
• Refractive Index: 1.496
• Boiling Point: 289.8 ºC at 760 mmHg
• PKA: 13.34±0.20(Predicted)
• Flash Point: 129.1 ºC
• PSA: 29.10000
• Density: 1.391 g/cm³
• LogP: 2.33800
• Storage Temp.: Keep Cold

Purity/Quality:

99% ^*data from raw suppliers

6-(Trifluoromethyl)oxindole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-43
• Safety Statements: 36/37-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-(Trifluoromethyl)indolin-2-one is used in preparation of oxindole derivatives as neuronal death inhibitors.

Technology Process of 6-TRIFLUOROMETHYLOXINDOLE

There total 7 articles about 6-TRIFLUOROMETHYLOXINDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

→ 6-trifluoromethyl-2-indolinone (1735-89-3)

Guidance literature:

Reference yield: 54.0%

2-(2-nitro-4-(trifluoromethyl)phenyl)acetic acid (1735-91-7) → 6-trifluoromethyl-2-indolinone (1735-89-3) + C9H6F3NO2 (951883-90-2)

Guidance literature:

2-(2-nitro-4-(trifluoromethyl)phenyl)acetic acid; With 1,10-Phenanthroline; platinum on carbon; hydrogen; In ethanol; at 20 ℃; under 7500.75 Torr; Flow reactor; Green chemistry;

With acetic acid; In ethanol; at 20 ℃; Green chemistry;

DOI:10.1016/j.tetlet.2017.01.008

Reference yield:

methyl 2-(2-nitro-4-(trifluoromethyl)phenyl)acetate (13544-07-5) → 6-trifluoromethyl-2-indolinone (1735-89-3)

Guidance literature:

palladium;

upstream raw materials:

methyl 2-(2-nitro-4-(trifluoromethyl)phenyl)acetate

2-(2-nitro-4-(trifluoromethyl)phenyl)acetic acid

diethyl 2-(2-nitro-4-(trifluoromethyl)phenyl)malonate

dimethyl 2-(2-nitro-4-trifluoromethylphenyl)malonate

Downstream raw materials:

1-(3,5-dimethyl-phenyl)-6-trifluoromethyl-1,3-dihydro-indol-2-one

Methyl-(7-trifluoromethyl-2,3,4,9-tetrahydro-thiopyrano[2,3-b]indol-4-ylmethyl)-amine; hydrochloride

(2'R,3'S,4'R,5'R)-1'-((1R,2S)-2-Hydroxy-1,2-diphenyl-ethyl)-2'-isobutyl-2-oxo-4'-phenyl-6-trifluoromethyl-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide

Refernces

• 1、 Cao, Jingrong,Gao, Huai,Bemis, Guy,Salituro, Francesco,Ledeboer, Mark,Harrington, Edmund,Wilke, Susanne,Taslimi, Paul,Pazhanisamy,Xie, Xiaoling,Jacobs, Marc,Green, Jeremy. "Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors". scheme or table. p. 2891 - 2895. Retrieved 2010/01/16.
• 2、 -. "FORMULATIONS FOR PHARMACEUTICAL AGENTS IONIZABLE AS FREE ACIDS OR FREE BASES". Page/Page column 171. . Retrieved 2008/06/13.