Thiopyrano(2,3-b)indole, 2,3,4,9-tetrahydro-4-((methylamino)methyl)-7-(trifluoromethyl)-, monohydrochloride

Base Information

Chemical Name:Thiopyrano(2,3-b)indole, 2,3,4,9-tetrahydro-4-((methylamino)methyl)-7-(trifluoromethyl)-, monohydrochloride
CAS No.:73425-84-0
Molecular Formula:C₁₄H₁₅F₃N₂S*ClH
Molecular Weight:336.809
Hs Code.:
DSSTox Substance ID:DTXSID70994169

Synonyms:2,3,4,9-Tetrahydro-N-methyl-7-(trifluoromethyl)thiopyrano(2,3-b)indole-4-methylamine HCl;Thiopyrano(2,3-b)indole-4-methylamine, 2,3,4,9-tetrahydro-N-methyl-7-(trifluoromethyl)-, HCl;73425-84-0;Thiopyrano(2,3-b)indole, 2,3,4,9-tetrahydro-4-((methylamino)methyl)-7-(trifluoromethyl)-, monohydrochloride;C14H15F3N2S.ClH;DTXSID70994169;C14-H15-F3-N2-S.Cl-H;LS-153304;N-Methyl-1-[7-(trifluoromethyl)-2,3,4,9-tetrahydrothiopyrano[2,3-b]indol-4-yl]methanamine--hydrogen chloride (1/1)

Suppliers and Price of Thiopyrano(2,3-b)indole, 2,3,4,9-tetrahydro-4-((methylamino)methyl)-7-(trifluoromethyl)-, monohydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Thiopyrano(2,3-b)indole, 2,3,4,9-tetrahydro-4-((methylamino)methyl)-7-(trifluoromethyl)-, monohydrochloride

Chemical Property:

Vapor Pressure:8.11E-07mmHg at 25°C
Boiling Point:406.5°C at 760 mmHg
Flash Point:199.6°C
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:336.0674819
Heavy Atom Count:21
Complexity:350

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNCC1CCSC2=C1C3=C(N2)C=C(C=C3)C(F)(F)F.Cl

Technology Process of Thiopyrano(2,3-b)indole, 2,3,4,9-tetrahydro-4-((methylamino)methyl)-7-(trifluoromethyl)-, monohydrochloride

There total 4 articles about Thiopyrano(2,3-b)indole, 2,3,4,9-tetrahydro-4-((methylamino)methyl)-7-(trifluoromethyl)-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 73425-18-0
7-trifluoromethyl-2,3,4,9-tetrahydro-thiopyrano[2,3-b]indole-4-carbaldehyde

: 74-89-5
methylamine

: 73425-84-0
Methyl-(7-trifluoromethyl-2,3,4,9-tetrahydro-thiopyrano[2,3-b]indol-4-ylmethyl)-amine; hydrochloride

Guidance literature:: With hydrogenchloride; sodium tetrahydroborate;
DOI:10.1248/cpb.32.877

Reference yield:

: 1735-89-3
6-trifluoromethyl-2-indolinone

: 73425-84-0
Methyl-(7-trifluoromethyl-2,3,4,9-tetrahydro-thiopyrano[2,3-b]indol-4-ylmethyl)-amine; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / P₂S₅, NaHCO₃ / tetrahydrofuran / 3 h / Ambient temperature

2: K₂CO₃

3: Heating

4: 79 percent / 1) NaBH₄; 2) HCl

With hydrogenchloride; sodium tetrahydroborate; tetraphosphorus decasulfide; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran;
DOI:10.1248/cpb.32.877

Reference yield:

: 73425-12-4
6-Trifluoromethyl-1,3-dihydro-indole-2-thione

: 73425-84-0
Methyl-(7-trifluoromethyl-2,3,4,9-tetrahydro-thiopyrano[2,3-b]indol-4-ylmethyl)-amine; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃

2: Heating

3: 79 percent / 1) NaBH₄; 2) HCl

With hydrogenchloride; sodium tetrahydroborate; potassium carbonate;
DOI:10.1248/cpb.32.877