(2'R,3'S,4'R,5'R)-1'-((1R,2S)-2-Hydroxy-1,2-diphenyl-ethyl)-2'-isobutyl-2-oxo-4'-phenyl-6-trifluoromethyl-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide

Base Information

• Chemical Name: (2'R,3'S,4'R,5'R)-1'-((1R,2S)-2-Hydroxy-1,2-diphenyl-ethyl)-2'-isobutyl-2-oxo-4'-phenyl-6-trifluoromethyl-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide
• CAS No.: 865080-02-0
• Molecular Formula: C₃₉H₄₀F₃N₃O₃
• Molecular Weight: 655.76
• Mol file: 865080-02-0.mol

Synonyms:(2'R,3'S,4'R,5'R)-1'-((1R,2S)-2-Hydroxy-1,2-diphenyl-ethyl)-2'-isobutyl-2-oxo-4'-phenyl-6-trifluoromethyl-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide

Chemical Property of (2'R,3'S,4'R,5'R)-1'-((1R,2S)-2-Hydroxy-1,2-diphenyl-ethyl)-2'-isobutyl-2-oxo-4'-phenyl-6-trifluoromethyl-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2'R,3'S,4'R,5'R)-1'-((1R,2S)-2-Hydroxy-1,2-diphenyl-ethyl)-2'-isobutyl-2-oxo-4'-phenyl-6-trifluoromethyl-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide

There total 4 articles about (2'R,3'S,4'R,5'R)-1'-((1R,2S)-2-Hydroxy-1,2-diphenyl-ethyl)-2'-isobutyl-2-oxo-4'-phenyl-6-trifluoromethyl-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C37H33F3N2O3 + dimethyl amine (124-40-3) → (2'R,3'S,4'R,5'R)-1'-((1R,2S)-2-Hydroxy-1,2-diphenyl-ethyl)-2'-isobutyl-2-oxo-4'-phenyl-6-trifluoromethyl-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide (865080-02-0)

Guidance literature:

In tetrahydrofuran;

DOI:10.1016/j.tetlet.2005.06.114

Reference yield:

benzaldehyde (100-52-7) → (2'R,3'S,4'R,5'R)-1'-((1R,2S)-2-Hydroxy-1,2-diphenyl-ethyl)-2'-isobutyl-2-oxo-4'-phenyl-6-trifluoromethyl-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide (865080-02-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 57 percent / KF; Al₂O₃ / 0.08 h / Irradiation

2: toluene / 5 h / 70 °C

3: 75 percent / tetrahydrofuran

With aluminum oxide; potassium fluoride; In tetrahydrofuran; toluene;

DOI:10.1016/j.tetlet.2005.06.114

Reference yield:

3-[1-Phenyl-meth-(E)-ylidene]-6-trifluoromethyl-1,3-dihydro-indol-2-one (865079-95-4) → (2'R,3'S,4'R,5'R)-1'-((1R,2S)-2-Hydroxy-1,2-diphenyl-ethyl)-2'-isobutyl-2-oxo-4'-phenyl-6-trifluoromethyl-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide (865080-02-0)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 5 h / 70 °C

2: 75 percent / tetrahydrofuran

In tetrahydrofuran; toluene;

DOI:10.1016/j.tetlet.2005.06.114

upstream raw materials:

dimethyl amine

3-[1-Phenyl-meth-(E)-ylidene]-6-trifluoromethyl-1,3-dihydro-indol-2-one

6-trifluoromethyl-2-indolinone

benzaldehyde