Technology Process of (S)-4-(2-(benzhydryloxy)-3-(2,5-dimethoxyphenyl)-3-oxopropyl)phenyl pivalate
There total 9 articles about (S)-4-(2-(benzhydryloxy)-3-(2,5-dimethoxyphenyl)-3-oxopropyl)phenyl pivalate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
cesium hydroxide;
O-allyl-1-(2,3,4-trifluorobenzyl)hydrocinchonidinium bromide;
In
hexane; dichloromethane;
at -35 ℃;
for 24h;
Title compound not separated from byproducts;
DOI:10.1021/jo051568z
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 80 percent / sodium hydride / tetrahydrofuran / 2.5 h / 0 - 20 °C
2: 81 percent / lithium bromide; methanesulfonyl chloride; triethylamine / tetrahydrofuran / 2 h / 0 °C
3: cesium hydroxide monohydrate; N-trifluorobenzylhydrocinchonidinium bromide-based compound / CH2Cl2; hexane / 24 h / -35 °C
With
cesium hydroxide; N-trifluorobenzylhydrocinchonidinium bromide-based compound; sodium hydride; methanesulfonyl chloride; triethylamine; lithium bromide;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo061395t
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 4-dimethylaminopyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; N,N-diisopropylethylamine / CH2Cl2 / 25 h / 0 - 20 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 3 h / 0 °C
2.2: 2.24 g / tetrahydrofuran; hexane / 0.25 h / -40 °C
3.1: cesium hydroxide monohydrate; N-trifluorobenzylhydrocinchonidinium bromide-based compound / CH2Cl2; hexane / 24 h / -35 °C
With
dmap; cesium hydroxide; n-butyllithium; N-trifluorobenzylhydrocinchonidinium bromide-based compound; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo061395t
