(S)-4-(2-(benzhydryloxy)-3-(2,5-dimethoxyphenyl)-3-oxopropyl)phenyl pivalate

Base Information

Chemical Name:(S)-4-(2-(benzhydryloxy)-3-(2,5-dimethoxyphenyl)-3-oxopropyl)phenyl pivalate
CAS No.:869093-41-4
Molecular Formula:C₃₅H₃₆O₆
Molecular Weight:552.667
Hs Code.:

Synonyms:(S)-4-(2-(benzhydryloxy)-3-(2,5-dimethoxyphenyl)-3-oxopropyl)phenyl pivalate

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Chemical Property of (S)-4-(2-(benzhydryloxy)-3-(2,5-dimethoxyphenyl)-3-oxopropyl)phenyl pivalate

Chemical Property:

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Technology Process of (S)-4-(2-(benzhydryloxy)-3-(2,5-dimethoxyphenyl)-3-oxopropyl)phenyl pivalate

There total 9 articles about (S)-4-(2-(benzhydryloxy)-3-(2,5-dimethoxyphenyl)-3-oxopropyl)phenyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59012-91-8
2,2-dimethyl-propionic acid 4-hydroxymethyl-phenyl ester

: 736933-15-6
2-(benzhydryloxy)-1-(2,5-dimethoxyphenyl)-ethanone

: 869093-41-4
(S)-4-(2-(benzhydryloxy)-3-(2,5-dimethoxyphenyl)-3-oxopropyl)phenyl pivalate

: (R)-4-(2-(benzhydryloxy)-3-(2,5-dimethoxyphenyl)-3-oxopropyl)phenyl pivalate

Guidance literature:: With cesium hydroxide; O-allyl-1-(2,3,4-trifluorobenzyl)hydrocinchonidinium bromide; In hexane; dichloromethane; at -35 ℃; for 24h; Title compound not separated from byproducts;
DOI:10.1021/jo051568z

Reference yield:

: 623-05-2
(4-hydroxyphenyl)methanol

: 869093-41-4
(S)-4-(2-(benzhydryloxy)-3-(2,5-dimethoxyphenyl)-3-oxopropyl)phenyl pivalate

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / sodium hydride / tetrahydrofuran / 2.5 h / 0 - 20 °C

2: 81 percent / lithium bromide; methanesulfonyl chloride; triethylamine / tetrahydrofuran / 2 h / 0 °C

3: cesium hydroxide monohydrate; N-trifluorobenzylhydrocinchonidinium bromide-based compound / CH₂Cl₂; hexane / 24 h / -35 °C

With cesium hydroxide; N-trifluorobenzylhydrocinchonidinium bromide-based compound; sodium hydride; methanesulfonyl chloride; triethylamine; lithium bromide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo061395t

Reference yield:

: 21409-25-6
Acetic acid,2-(diphenylmethoxy)

: 869093-41-4
(S)-4-(2-(benzhydryloxy)-3-(2,5-dimethoxyphenyl)-3-oxopropyl)phenyl pivalate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-dimethylaminopyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; N,N-diisopropylethylamine / CH₂Cl₂ / 25 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 3 h / 0 °C

2.2: 2.24 g / tetrahydrofuran; hexane / 0.25 h / -40 °C

3.1: cesium hydroxide monohydrate; N-trifluorobenzylhydrocinchonidinium bromide-based compound / CH₂Cl₂; hexane / 24 h / -35 °C

With dmap; cesium hydroxide; n-butyllithium; N-trifluorobenzylhydrocinchonidinium bromide-based compound; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo061395t